1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

DEL-22379 

Cat. No.: HY-18932 Purity: 99.84%
Data Sheet SDS Handling Instructions

DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM.

For research use only. We do not sell to patients.
DEL-22379 Chemical Structure

DEL-22379 Chemical Structure

CAS No. : 181223-80-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $171 In-stock
5 mg $155 In-stock
10 mg $255 In-stock
50 mg $855 In-stock
100 mg $1500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM. IC50 value: 0.5 μM Target: ERK in vitro: DEL-22379 inhibits ERK dimerization without affecting its phosphorylation. DEL-22379 blocks proliferation of tumor cells harboring RASERK pathway oncogenes. Pretreating cells with DEL-22379 inhibits EGF-stimulated RSK1 phosphorylation, with estimated IC50 values of 500 nM for DEL-22379.[1] in vivo: In animal tumor models, DEL-22379 induces apoptosis, preventing tumor progression.DEL-22379 abolishes EGF-induced co-immunoprecipitation of ectopic ERK2 molecules tagged with hemagglutinin (HA) or FLAG epitopes, with an estimated half-maximal inhibitory concentration (IC50) of 0.5 uM.[1]

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2496 mL 11.2478 mL 22.4957 mL
5 mM 0.4499 mL 2.2496 mL 4.4991 mL
10 mM 0.2250 mL 1.1248 mL 2.2496 mL
References
Molecular Weight

444.53

Formula

C₂₆H₂₈N₄O₃

CAS No.

181223-80-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
DEL-22379
Cat. No.:
HY-18932
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