1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. Gemigliptin

Gemigliptin (Synonyms: LC15-0444)

Cat. No.: HY-14892
Handling Instructions

Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin exhibits potent anti-glycation properties. Gemigliptin can be used for the research of advanced glycation end products (AGE)-related diabetic complications.

For research use only. We do not sell to patients.

Gemigliptin Chemical Structure

Gemigliptin Chemical Structure

CAS No. : 911637-19-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 121 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 330 Get quote
100 mg USD 520 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin exhibits potent anti-glycation properties. Gemigliptin can be used for the research of advanced glycation end products (AGE)-related diabetic complications[1][2].

IC50 & Target

IC50: 10.3 nM (human recombinant DPP-4)[2]

In Vitro

Gemigliptin dose-dependently inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1].
Gemigliptin dose-dependently suppressed the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1].
Gemigliptin is a competitive inhibitor with a Ki of 7.25 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Gemigliptin (100 mg/kg; i.g.; daily; for 12 weeks) inhibits AGEs formation and AGE cross-links in vivo[1].
Gemigliptin dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/KsJ-db/db mice (7 weeks old)[1]
Dosage: 100 mg/kg
Administration: Oral gavage, daily, for 12 weeks
Result: Significantly reduced circulating AGE levels by 44.5% in serum.
Clinical Trial
Molecular Weight

489.36

Formula

C₁₈H₁₉F₈N₅O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (102.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0435 mL 10.2174 mL 20.4349 mL
5 mM 0.4087 mL 2.0435 mL 4.0870 mL
10 mM 0.2043 mL 1.0217 mL 2.0435 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Gemigliptin
Cat. No.:
HY-14892
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