Gemigliptin hydrochloride
Gemigliptin hydrochloride is the hydrochloride salt of Gemigliptin (HY-14892). Gemigliptin hydrochloride is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin hydrochloride exhibits potent anti-glycation properties. Gemigliptin hydrochloride can be used for the research of advanced glycation end products (AGE)-related diabetic complications.
For research use only. We do not sell to patients.
- CAS No.: 1523530-62-2
- Formula: C18H20ClF8N5O2
- Molecular Weight:525.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DPP-4 |
Chemical Information
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CAS No. 1523530-62-2
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Molecular Weight 525.82
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Formula C18H20ClF8N5O2
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SMILES
FC(F)(C1=C2C(CN(CC2)C(C[C@H](N)CN3CC(F)(CCC3=O)F)=O)=NC(C(F)(F)F)=N1)F.Cl
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Synonyms
LC15-0444 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jung E, et al. Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo. Eur J Pharmacol. 2014 Dec 5;744:98-102. [Content Brief]
[2]. Kim SH, et al. Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo. Eur J Pharmacol. 2016 Oct 5;788:54-64. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gemigliptin hydrochloride Related Classifications
HY-14892C Related Classifications
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