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  3. GCGR
  4. Glucagon-like peptide 1 (1-37), human

Glucagon-like peptide 1 (1-37), human  (Synonyms: GLP-1 (1-37) human)

製品番号: HY-P1145 純度: 99.70%
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Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.

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Glucagon-like peptide 1 (1-37), human

Glucagon-like peptide 1 (1-37), human 構造式

CAS 番号 : 87805-34-3

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1 mg $440 在庫あり
5 mg $880 在庫あり
10 mg $1280 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of Glucagon-like peptide 1 (1-37), human:

Glucagon-like peptide 1 (1-37), human 関連抗体

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製品説明

Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.

IC50 & Target

GLP-1 receptor[1]
体外実験

Glucagon-like peptide-1 (GLP-1) is produced by the posttranslational processing of proglucagon and acts as a regulator of various homeostatic events. GLP-1(1-37) is more stable than GLP-1(7-37), with 94.7% of the initial amount of peptide left after a 4h exposure to mouse serum. GLP-1(1-37) is confirmed to be a highly potent agonist of the GLP-1 receptor (GLP-1R) by measuring the expression of the luciferase reporter gene expression in transiently transfected human embryonic kidney (HEK293) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glucagon-like peptide 1 (1-37), human 関連抗体
体内実験

GLP-1(1–37) decreased glycemic excursion in a dose-dependent. The administration of GLP-1(1–37) or GLP-1(7–37) markedly decrease blood glucose levels at 15 min and 30 min compared with the control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4169.48

分子式

C186H275N51O59
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Sequence Shortening

HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション
参考文献
細胞実験
[1]

HEK293 cells (5×104) are seeded in a 96-well plate and transiently cotransfected with the GLP-1R plasmid and the CRE-luciferase reporter plasmid. After a 48 h transfection, different concentrations of GLP-1(1–37) or GLP-1(7–37) are added, and the cells are incubated for 5 h. The cells are harvested for a luciferase assay using a luciferase assay[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
動物実験
[1]

Mice[1]

The normal KM mice are fasted for 16 h before the administration (i.p.) of GLP-1 and glucose. GLP-1(1-37) (25 nmol/kg) with or without exendin(9-39) (250 nmol/kg) is given in combination with glucose (4 g/kg). GLP-1(7-37) (25 nmol/kg) with or without exendin(9-39) (250 nmol/kg) is also administrated in combination with glucose (4 g/kg). The control group is treated with saline (NaCl, 9 g/l) and glucose (4 g/kg). The IPGTT is carried out at 0, 15, 30 and 60 min after glucose and protein administration, and the blood glucose levels are measured as described above[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
参考文献
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Glucagon-like peptide 1 (1-37), human Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucagon-like peptide 1 (1-37), human87805-34-3GLP-1 (1-37) humanGCGRGlucagon ReceptorInhibitorinhibitorinhibit

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製品名:
Glucagon-like peptide 1 (1-37), human
製品番号:
HY-P1145
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