2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. N-Demethyl Ivabradine hydrochloride

N-Demethyl Ivabradine hydrochloride  (Synonyms: Ivabradine metabolite N-Demethyl Ivabradine hydrochloride)

Art. -Nr.: HY-12778 Reinheit: 99.63%
COA
SDS
Handling Instructions Technical Support

N-Demethyl Ivabradine (hydrochloride) is a metabolite of Ivabradine, which is a specific inhibitor of the funny channel.

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N-Demethyl Ivabradine hydrochloride

N-Demethyl Ivabradine hydrochloride Chemische Struktur

CAS. Nr. : 1246638-08-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
1 mg Auf Lager
5 mg Auf Lager
10 mg Auf Lager
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Other Forms of N-Demethyl Ivabradine hydrochloride:

N-Demethyl Ivabradine hydrochloride Related Antibodies

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Beschreibung

N-Demethyl Ivabradine (hydrochloride) is a metabolite of Ivabradine, which is a specific inhibitor of the funny channel.

Molekulargewicht

491.02

Formel

C26H35ClN2O5
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCCNC[C@@H]2C(C=C(OC)C(OC)=C3)=C3C2)CCC4=CC(OC)=C(OC)C=C4C1.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 66.67 mg/mL (135.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0366 mL 10.1829 mL 20.3658 mL
5 mM 0.4073 mL 2.0366 mL 4.0732 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation

Purity: 99.63%

SDS (393 KB)

COA (249 KB) HNMR (274 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0366 mL 10.1829 mL 20.3658 mL 50.9144 mL
5 mM 0.4073 mL 2.0366 mL 4.0732 mL 10.1829 mL
10 mM 0.2037 mL 1.0183 mL 2.0366 mL 5.0914 mL
15 mM 0.1358 mL 0.6789 mL 1.3577 mL 3.3943 mL
20 mM 0.1018 mL 0.5091 mL 1.0183 mL 2.5457 mL
25 mM 0.0815 mL 0.4073 mL 0.8146 mL 2.0366 mL
30 mM 0.0679 mL 0.3394 mL 0.6789 mL 1.6971 mL
40 mM 0.0509 mL 0.2546 mL 0.5091 mL 1.2729 mL
50 mM 0.0407 mL 0.2037 mL 0.4073 mL 1.0183 mL
60 mM 0.0339 mL 0.1697 mL 0.3394 mL 0.8486 mL
80 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6364 mL
100 mM 0.0204 mL 0.1018 mL 0.2037 mL 0.5091 mL
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N-Demethyl Ivabradine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Demethyl Ivabradine1246638-08-3Ivabradine metabolite N-Demethyl IvabradineDrug MetaboliteInhibitorinhibitorinhibit

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