2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP  (Synonyms: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate)

Cat. No.: HY-20336 Pureté: 98.68%
COA
SDS
Instruction de manipulation Technical Support

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs.

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Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP Chemical Structure

CAS No. : 159857-81-5

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Based on 6 publication(s) in Google Scholar

Other Forms of Mc-Val-Cit-PABC-PNP:

Mc-Val-Cit-PABC-PNP Related Antibodies

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • Activité biologique

  • Pureté et documentation

  • Références

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Description

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs[1][2].

IC50 & Target

Protease Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mc-Val-Cit-PABC-PNP Related Antibodies
Masse moléculaire

737.76

Formule

C35H43N7O11
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (135.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3555 mL 6.7773 mL 13.5545 mL
5 mM 0.2711 mL 1.3555 mL 2.7109 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 98.75%

SDS (396 KB)

COA (255 KB) HNMR (307 KB) RP-HPLC (256 KB) LCMS (97 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3555 mL 6.7773 mL 13.5545 mL 33.8864 mL
5 mM 0.2711 mL 1.3555 mL 2.7109 mL 6.7773 mL
10 mM 0.1355 mL 0.6777 mL 1.3555 mL 3.3886 mL
15 mM 0.0904 mL 0.4518 mL 0.9036 mL 2.2591 mL
20 mM 0.0678 mL 0.3389 mL 0.6777 mL 1.6943 mL
25 mM 0.0542 mL 0.2711 mL 0.5422 mL 1.3555 mL
30 mM 0.0452 mL 0.2259 mL 0.4518 mL 1.1295 mL
40 mM 0.0339 mL 0.1694 mL 0.3389 mL 0.8472 mL
50 mM 0.0271 mL 0.1355 mL 0.2711 mL 0.6777 mL
60 mM 0.0226 mL 0.1130 mL 0.2259 mL 0.5648 mL
80 mM 0.0169 mL 0.0847 mL 0.1694 mL 0.4236 mL
100 mM 0.0136 mL 0.0678 mL 0.1355 mL 0.3389 mL
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Mc-Val-Cit-PABC-PNP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mc-Val-Cit-PABC-PNP159857-81-5Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenylADC LinkerAntibody-drug conjugates linkerADCscathepsin cleavableADC synthesisInhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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