Mebeverine hydrochloride

Cat. No.: HY-A0078 Pureza: 99.85%: Ficha de datos
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Mebeverine hydrochloride, a β-phenylethylamine derivative, is a musculotropic agent that potently blocks intestinal peristalsis. Mebeverine directly blocks voltage-operated sodium channels and inhibits intracellular calcium accumulation.

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Mebeverine hydrochloride Estructura química

No. CAS : 2753-45-9

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Other Forms of Mebeverine hydrochloride:

Mebeverine-d₆ hydrochloride Obtener un presupuesto
Mebeverine hydrochloride (Standard) Obtener un presupuesto

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Sodium Channel:

Ver todas las isoformas

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8 Na_v1.9

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Descripciòn

In Vitro

Mebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6×10^-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3×10^-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6×10^-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

466.01

Fòrmula

C₂₅H₃₆ClNO₅

No. CAS

2753-45-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCCCCN(CC)C(C)CC1=CC=C(OC)C=C1)C2=CC=C(OC)C(OC)=C2.[H]Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : ≥ 155 mg/mL (332.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1459 mL	10.7294 mL	21.4588 mL
5 mM	0.4292 mL	2.1459 mL	4.2918 mL
10 mM	0.2146 mL	1.0729 mL	2.1459 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.85%

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Ficha de datos (269 KB) SDS (392 KB)

COA (244 KB) HNMR (172 KB) LCMS (95 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Annaházi A, et al. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol. 2014;20(20):6031-6043. [Content Brief]

[2]. Den Hertog A, et al. Modification of alpha 1-receptor-operated channels by mebeverine in smooth muscle cells of guinea-pig taenia caeci. Eur J Pharmacol. 1987 Jun 26;138(3):367-74. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1459 mL	10.7294 mL	21.4588 mL	53.6469 mL
	5 mM	0.4292 mL	2.1459 mL	4.2918 mL	10.7294 mL
	10 mM	0.2146 mL	1.0729 mL	2.1459 mL	5.3647 mL
	15 mM	0.1431 mL	0.7153 mL	1.4306 mL	3.5765 mL
	20 mM	0.1073 mL	0.5365 mL	1.0729 mL	2.6823 mL
	25 mM	0.0858 mL	0.4292 mL	0.8584 mL	2.1459 mL
	30 mM	0.0715 mL	0.3576 mL	0.7153 mL	1.7882 mL
	40 mM	0.0536 mL	0.2682 mL	0.5365 mL	1.3412 mL
	50 mM	0.0429 mL	0.2146 mL	0.4292 mL	1.0729 mL
	60 mM	0.0358 mL	0.1788 mL	0.3576 mL	0.8941 mL
	80 mM	0.0268 mL	0.1341 mL	0.2682 mL	0.6706 mL
	100 mM	0.0215 mL	0.1073 mL	0.2146 mL	0.5365 mL