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  3. Micafungin sodium

Micafungin sodium (Synonyms: FK 463 (sodium))

Cat. No.: HY-16321 Purity: >98.0%
Handling Instructions

Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.

For research use only. We do not sell to patients.

Micafungin sodium Chemical Structure

Micafungin sodium Chemical Structure

CAS No. : 208538-73-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 171 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 456 In-stock
Estimated Time of Arrival: December 31
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Based on 3 publication(s) in Google Scholar

Other Forms of Micafungin sodium:

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  • Biological Activity

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Description

Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.

In Vitro

Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts[1]. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone[2].

In Vivo

Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals[2].

Clinical Trial
Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (24.76 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7738 mL 3.8692 mL 7.7384 mL
5 mM 0.1548 mL 0.7738 mL 1.5477 mL
10 mM 0.0774 mL 0.3869 mL 0.7738 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

Each fungal isolate is incubated statically in yeast-maltose (YM) agar broth for 24 h at 30°C. Cryptococcus neoformans YC203 is grown in YM broth medium for 20 h at 30°C with shaking at 200 r.p.m. A cell suspension is prepared by washing the cultured cells once with sterile saline. A. fumigatus FP1305 is cultured on a potato dextrose agar (PDA) slant for 4 days, and spores are then harvested in sterile saline and collected by filtering through gauze. Antifungal activity against all isolates, with the exception of C. neoformans, is measured by the micro-broth dilution method in 96-well culture plates using RPMI 1640 medium supplemented with l-glutamine, but without sodium bicarbonate, and buffered to pH 7.0 with 0.165 m MOPS. ForC. neoformans, yeast nitrogen base-glucose (YNBD) medium is used. For the assay, the test microorganism is inoculated into each well to yield 1×105 CFU/well, and the plates are then incubated for 20 h or 48 h at 37°C. Two end points are determined by microscopic observation: MEC, which is defined as a substantial reduction in fungal growth, and MIC, which is defined as a complete inhibition of growth.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Eight groups of ten female DBA/2 mice (7 weeks old) are intravenously injected with 2.0×106 A. fumigatus FP1305 spores. The test groups receive the following treatments: AMPH at 1 mg/kg of body weight/dose given intraperitoneally (i.p.) once daily (q.d.); micafungin at 0.1, 0.32 or 1 mg/kg of body weight/dose given subcutaneously (s.c.) (q.d.); micafungin given s.c. (0.1, 0.32 or 1 mg/kgq.d.) plus KB425796-C given i.p. (32 mg/kg) twice daily (b.i.d.); and saline (b.i.d.). Drugs are administered on days 1 and 2. Five mice in each group are killed 1 day after the completion of treatment. The livers and kidneys are aseptically removed, and each organ is then homogenized in 5 mL sterile saline. Serial 10-fold dilutions of the homogenates are plated on PDA and incubated for 48 h at 37°C, and the numbers of CFU per gram of tissue are then calculated. The survival rate of remaining five mice of each group are examined daily for 31 days after the challenge.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1292.26

Formula

C₅₆H₇₀N₉NaO₂₃S

CAS No.

208538-73-2

SMILES

O=S(OC1=CC([[email protected]](O)[[email protected]@H](O)C(NC(C2N(C(C(NC([[email protected]]([H])(C[[email protected]@H](O)[[email protected]@H](O)NC(C3N(C(C([[email protected]](O)CC(N)=O)N4)=O)C[[email protected]](C)[[email protected]@H]3O)=O)NC(C5=CC=C(C6=NOC(C7=CC=C(OCCCCC)C=C7)=C6)C=C5)=O)=O)[[email protected]](O)C)=O)C[[email protected]](O)C2)=O)C4=O)=CC=C1O)([O-])=O.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
Micafungin sodium
Cat. No.:
HY-16321
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Micafungin sodium

Cat. No.: HY-16321