2. Immunology/Inflammation
  3. Nuclear Factor of activated T Cells (NFAT)
  4. NFAT Inhibitor-1

NFAT Inhibitor-1  (Synonyms: VIVIT peptide)

Cat. No.: HY-P1026 Pureza: 99.89%
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NFAT Inhibitor (VIVIT peptide) is an inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.

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Síntesis de péptidos personalizados

No. CAS : 249537-73-3

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1 mg En stock
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg   Obtener un presupuesto  
200 mg   Obtener un presupuesto  

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Revisión del cliente

Based on 14 publication(s) in Google Scholar

NFAT Inhibitor-1 Related Antibodies

Top Publications Citing Use of Products

    NFAT Inhibitor-1 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460.  [Abstract]

    VIVIT (1 μM; 14 days) inhibits the protein expression of NFATC2 in hLESCs.

    NFAT Inhibitor-1 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460.  [Abstract]

    VIVIT (1 μM; 14 days) inhibits the effect of WNT16b on cell proliferation in hLESCs.

    NFAT Inhibitor-1 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460.  [Abstract]

    VIVIT (1 μM; 14 days) significantly inhibits the expression of WNT16b-promoting cell proliferation marker Ki67 and the putative hLESC marker ΔNp63α in hLESCs.

    • Actividad biológica

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    NFAT Inhibitor (VIVIT peptide) is an inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2].

    IC50 & Target

    Nuclear factor of activated Tcells (NFAT)[1][2]
    In Vitro

    NFAT Inhibitor-1 treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with NFAT Inhibitor-1 significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    NFAT Inhibitor-1 Related Antibodies

    Western Blot Analysis[2]

    Cell Line: Human peripheral blood CD14+ monocytes
    Concentration: 10 μM
    Incubation Time: 24 hours or 21 days
    Result: Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.
    Peso molecular

    1683.93

    Fòrmula

    C75H118N20O22S
    No. CAS
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu
    Sequence Shortening

    MAGPHPVIVITGPHEE
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvente y solubilidad
    In Vitro: 

    H2O : 100 mg/mL (59.38 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.5938 mL 2.9692 mL 5.9385 mL
    5 mM 0.1188 mL 0.5938 mL 1.1877 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (29.69 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureza y Documentación
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 0.5938 mL 2.9692 mL 5.9385 mL 14.8462 mL
    5 mM 0.1188 mL 0.5938 mL 1.1877 mL 2.9692 mL
    10 mM 0.0594 mL 0.2969 mL 0.5938 mL 1.4846 mL
    15 mM 0.0396 mL 0.1979 mL 0.3959 mL 0.9897 mL
    20 mM 0.0297 mL 0.1485 mL 0.2969 mL 0.7423 mL
    25 mM 0.0238 mL 0.1188 mL 0.2375 mL 0.5938 mL
    30 mM 0.0198 mL 0.0990 mL 0.1979 mL 0.4949 mL
    40 mM 0.0148 mL 0.0742 mL 0.1485 mL 0.3712 mL
    50 mM 0.0119 mL 0.0594 mL 0.1188 mL 0.2969 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    NFAT Inhibitor-1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NFAT Inhibitor-1249537-73-3VIVIT peptideNFAT Inhibitor1NFAT Inhibitor 1Nuclear Factor of activated T Cells (NFAT)NFATcell-permeabledephosphorylationtestosteroneNFAT-LucalcineurinMMP‐9TRAP cathepsin-KInhibitorinhibitorinhibit

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    Nombre del producto:
    NFAT Inhibitor-1
    Cat. No.:
    HY-P1026
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