2. 天然物
  3. Plants
  4. Leguminosae Fabaceae
  5. Pongamia pinnata (L.) Pierre

Pongamia pinnata (L.) Pierre

Pongamia pinnata (L.) Pierre (13):

製品番号 製品名 CAS 番号 純度 構造式
  • HY-121811
    Pongamol 484-33-3 99.81%
    Pongamol (Lanceolatin C) is an orally active flavonoid with an IC50 of 75 μM and a Ki of 58 μM against PTPase-1B, and an IC50 of 103.5 μM against intestinal α-Glycosidase. Pongamol reduces the release of IL‑1β, TNF‑α, COX‑2 and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, Aβ deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia.
    Pongamol
  • HY-N2848
    α-Lapachone 4707-33-9 99.51%
    α-Lapachone shows trypanocidal activity.
    α-Lapachone
  • HY-N13838
    8,9-Dehydro-7,9-diisobutyryloxythymol 22518-03-2
    8,9-Dehydro-7,9-diisobutyryloxythymol is a Thymol (HY-N6810) derivative, as well as an antibacterial agent. 8,9-Dehydro-7,9-diisobutyryloxythymol can be found in the aerial parts of Ageratina adenophora, with selective activity against Gram-positive bacterial strains including Bacillus cereus. 8,9-Dehydro-7,9-diisobutyryloxythymol does not exhibit detectable in vitro cytotoxic activity against human cancer cell lines. 8,9-Dehydro-7,9-diisobutyryloxythymol can be used for the research of bacterial infection.
    8,9-Dehydro-7,9-diisobutyryloxythymol
  • HY-N2742
    3,8-Dioxo-7α-hydroxy-4,11(12)-tetradehydrocadinanene 1423809-64-6
    3,8-Dioxo-7α-hydroxy-4,11(12)-tetradehydrocadinanene is a natural sesquiterpene.
    3,8-Dioxo-7α-hydroxy-4,11(12)-tetradehydrocadinanene
  • HY-N16513
    Muurol-4-ene-3,8-dione 105181-07-5
    Muurol-4-ene-3,8-dione (Compound 2), a sesquiterpene, is one of the main hepatotoxic components in Eupatorium adenophorum. Muurol-4-ene-3,8-dione has an inhibitory effect on the growth of both the normal human hepatocyte cell L02 and the human hepatocellular carcinoma cell HepG2 with IC50 values of 87.52 and 104.48 μM.
    Muurol-4-ene-3,8-dione
  • HY-N2802
    Euptox A 79491-71-7
    Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells.
    Euptox A
  • HY-N15414
    Demethoxykanugin 1668-33-3
    Demethoxykanugin (Desmethoxykanugin, compound 1) is a acetylcholine (AChE) inhibitor. Demethoxykanugin shows cell cytotoxicity agains Vero cells.
    Demethoxykanugin
  • HY-W928231
    Demethoxyencecalinol 71822-00-9
    Demethoxyencecalinol is a Phenols product that can be isolated from the herbs of Eupatorium adenophora.
    Demethoxyencecalinol
  • HY-N2804
    9-Oxoageraphorone 105181-06-4
    9-Oxoageraphorone is a Sesquiterpenoids product that can be isolated from the herbs of Eupatorium adenophorum.
    9-Oxoageraphorone
  • HY-N1806
    3-Acetoxy-4-cadinen-8-one 923950-05-4
    3-Acetoxy-4-cadinen-8-one is a Sesquiterpenoids product that can be isolated from the herbs of Eupatorium adenophorum..
    3-Acetoxy-4-cadinen-8-one
  • HY-N1805
    3-Acetoxy-4,7(11)-cadinadien-8-one 104975-02-2
    3-Acetoxy-4,7(11)-cadinadien-8-one is a Sesquiterpenoids product that can be isolated from the herbs of Eupatorium adenophorum.
    3-Acetoxy-4,7(11)-cadinadien-8-one
  • HY-N13444
    10β-Hydroxycadina-4,11(13)-dien-12,8β-olide 35001-23-1
    10β-Hydroxycadina-4,11(13)-dien-12,8β-olide is a natural product.
    10β-Hydroxycadina-4,11(13)-dien-12,8β-olide
  • HY-N2769
    9β-Hydroxy-ageraphorone 97372-53-7
    9β-Hydroxy-ageraphorone is a natural cadinene sesquiterpene compound.
    9β-Hydroxy-ageraphorone