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Products are for research use only. Not for human use. We do not sell to patients.

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PLX8394

HY-18972

(PLX-8394)

PLX8394

PLX8394 Chemical Structure

PLX8394 is a potent and selective inhibitor of B-RafV600E (IC50~5 nM).

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $167 In-stock
5 mg $140 In-stock
10 mg $240 In-stock
50 mg $750 In-stock
100 mg $1200 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €164 In-stock
5 mg €137 In-stock
10 mg €235 In-stock
50 mg €735 In-stock
100 mg €1176 In-stock
200 mg Get quote
500 mg Get quote

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Product name: PLX8394
Cat. No.: HY-18972

PLX8394 Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of PLX8394

PLX8394 is a potent and selective inhibitor of B-RafV600E (IC50~5 nM).
IC50 value: ~5 nM
Target: B-RafV600E
in vitro: PLX8394 potently inhibits phosphorylation of ERK1/2 in PRT #3 and PRT #4 cells in addition to parental cells. PLX8394 potently inhibits ERK1/2-driven GAL4-Elk1 reporter activity in PRT cells as well as parental cells. PLX8394 effectively reducs cyclin D3 and cyclin D1, phosphorylation of retinoblastoma protein, and expression of cyclin A2 in parental cells. PLX8394 reduces levels of these cell cycle markers in PRT #3 and PRT #4 cells. Consistent with these effects, PLX8394 inhibits EdU incorporation into PRT #3 and PRT #4 cells in S phase entry assays. PLX8394 inhibits ERK1/2 phosphorylation and the growth of vemurafenib-resistant cells harboring either a BRAF V600K/L505H double mutation or an transposon-induced, N-terminal truncated form of BRAF.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 542.53 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₅H₂₁F₃N₆O₃S
CAS No 1393466-87-9
Solvent & Solubility

DMSO: ≥ 39 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.8432 mL 9.2161 mL 18.4322 mL
5 mM 0.3686 mL 1.8432 mL 3.6864 mL
10 mM 0.1843 mL 0.9216 mL 1.8432 mL

References on PLX8394

Inhibitor Kit

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