1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. Piboserod

Piboserod  (Synonyms: SB-207266)

Cat. No.: HY-15574 Purity: 99.12%
COA Handling Instructions

Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.

For research use only. We do not sell to patients.

Piboserod Chemical Structure

Piboserod Chemical Structure

CAS No. : 152811-62-6

Size Price Stock Quantity
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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 172 In-stock
10 mM * 1 mL in DMSO USD 172 In-stock
5 mg USD 100 In-stock
10 mg USD 156 In-stock
50 mg USD 540 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Piboserod:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist. IC50 value: Target: 5-HT4 antagonist in vitro: Piboserod did not modify the basal contractions but concentration-dependently antagonized the ability of 5-HT to enhance bladder strip contractions to EFS. In presence of 1 and 100 nM of piboserod, the maximal 5-HT-induced potentiations were reduced to 45.0+/-7.9 and 38.7+/-8.7%, respectively [1]. in vivo: Piboserod significantly increased LVEF by 1.7% vs. placebo (CI 0.3, 3.2, P = 0.020), primarily through reduced end-systolic volume from 165 to 158 mL (P = 0.060). There was a trend for greater increase in LVEF (2.7%, CI -1.1, 6.6, P = 0.15) in a small subset of patients not on chronic beta-blocker therapy. There was no significant effect on neurohormones, quality of life, or exercise tolerance. Patients on piboserod reported more adverse events, but numbers were too small to identify specific safety issues [2]. Pretreatment with potent 5-HT4 ligands dose-dependently reduced striatal SB207145 concentration and the effective dose to achieve 50% receptor occupancy (ED50 ) values were 4.8, 2.0, 7.4, 9.9, 3.8 and 0.02 mg/kg for GR113808, piboserod, prucalopride, RS67333, TD8954 and PF04995274, respectively [3].

IC50 & Target

5-HT4 Receptor


Clinical Trial
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (67.66 mM; ultrasonic and warming and heat to 60°C)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7064 mL 13.5318 mL 27.0636 mL
5 mM 0.5413 mL 2.7064 mL 5.4127 mL
10 mM 0.2706 mL 1.3532 mL 2.7064 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.12%

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Piboserod Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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