1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. Piboserod hydrochloride

Piboserod hydrochloride  (Synonyms: SB-207266 hydrochloride)

Cat. No.: HY-15574A
Handling Instructions

Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist.

For research use only. We do not sell to patients.

Piboserod hydrochloride Chemical Structure

Piboserod hydrochloride Chemical Structure

CAS No. : 178273-87-5

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Other Forms of Piboserod hydrochloride:

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Piboserod hydrochloride

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  • Purity & Documentation

  • References

  • Customer Review


Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist. IC50 value: Target: 5-HT4 antagonist in vitro: Piboserod did not modify the basal contractions but concentration-dependently antagonized the ability of 5-HT to enhance bladder strip contractions to EFS. In presence of 1 and 100 nM of piboserod, the maximal 5-HT-induced potentiations were reduced to 45.0+/-7.9 and 38.7+/-8.7%, respectively [1]. in vivo: Piboserod significantly increased LVEF by 1.7% vs. placebo (CI 0.3, 3.2, P = 0.020), primarily through reduced end-systolic volume from 165 to 158 mL (P = 0.060). There was a trend for greater increase in LVEF (2.7%, CI -1.1, 6.6, P = 0.15) in a small subset of patients not on chronic beta-blocker therapy. There was no significant effect on neurohormones, quality of life, or exercise tolerance. Patients on piboserod reported more adverse events, but numbers were too small to identify specific safety issues [2]. Pretreatment with potent 5-HT4 ligands dose-dependently reduced striatal SB207145 concentration and the effective dose to achieve 50% receptor occupancy (ED50 ) values were 4.8, 2.0, 7.4, 9.9, 3.8 and 0.02 mg/kg for GR113808, piboserod, prucalopride, RS67333, TD8954 and PF04995274, respectively [3].

IC50 & Target

5-HT4 Receptor


Clinical Trial
Molecular Weight







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Piboserod hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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