2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Porcine dynorphin A(1-13)

Porcine dynorphin A(1-13)  (Synonyms: Dynorphin A Porcine Fragment 1-13)

Cat. No.: HY-P0088 Pureté: 99.86%
COA
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Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

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Synthèse de peptides personnalisée

Porcine dynorphin A(1-13)

Porcine dynorphin A(1-13) Chemical Structure

CAS No. : 72957-38-1

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5 mg En stock
10 mg En stock
25 mg En stock
50 mg   Obtenir un devis  
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Porcine dynorphin A(1-13) Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

IC50 & Target

κ Opioid Receptor/KOR

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
18 nM
Compound: Dynorphin A(1-13)
Binding affinity towards k-opioid receptor k-EL-2 mutant (wild-type) expressed in HEK cells
Binding affinity towards k-opioid receptor k-EL-2 mutant (wild-type) expressed in HEK cells
[PMID: 10753461]
HEK293 EC50
6 nM
Compound: Dynorphin A(1-13)
Binding affinity towards Mutant E203Q,D204N,D206N Opioid receptor kappa 1 expressed in HEK cells
Binding affinity towards Mutant E203Q,D204N,D206N Opioid receptor kappa 1 expressed in HEK cells
[PMID: 10753461]
HEK293 EC50
8 nM
Compound: Dynorphin A(1-13)
Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 expressed in HEK cells
Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 expressed in HEK cells
[PMID: 10753461]
In Vivo

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

1603.95

Formule

C75H126N24O15
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys
Sequence Shortening

YGGFLRRIRPKLK
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

H2O : ≥ 50 mg/mL (31.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6235 mL 3.1173 mL 6.2346 mL
5 mM 0.1247 mL 0.6235 mL 1.2469 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (62.35 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6235 mL 3.1173 mL 6.2346 mL 15.5865 mL
5 mM 0.1247 mL 0.6235 mL 1.2469 mL 3.1173 mL
10 mM 0.0623 mL 0.3117 mL 0.6235 mL 1.5587 mL
15 mM 0.0416 mL 0.2078 mL 0.4156 mL 1.0391 mL
20 mM 0.0312 mL 0.1559 mL 0.3117 mL 0.7793 mL
25 mM 0.0249 mL 0.1247 mL 0.2494 mL 0.6235 mL
30 mM 0.0208 mL 0.1039 mL 0.2078 mL 0.5196 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Porcine dynorphin A(1-13) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Porcine dynorphin A(1-13)72957-38-1Dynorphin A Porcine Fragment 1-13Opioid ReceptorInhibitorinhibitorinhibit

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