RU 58841 (Synonyms: PSK-3841; HMR-3841)

Name: RU 58841
Brand: MedChemExpress
SKU: HY-10561
Rating: 4.5 (0 reviews)

Cat. No.: HY-10561 Purity: 99.72%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen. RU 58841 has a dramatic effect on hair regrowth.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

RU 58841 화학구조

CAS No. : 154992-24-2

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of RU 58841:

RU 58841 (Standard) 견적 받기

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
순도&문서
References
고객리뷰

제품 설명

RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen. RU 58841 has a dramatic effect on hair regrowth^[1]^[2]^[3].

IC₅₀ & Target

Androgen receptor

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-453	IC₅₀	40 1 Compound: 4, RU-58841	Antagonist activity against human androgen receptor expressed in human MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced effect by luciferase receptor gene assay Antagonist activity against human androgen receptor expressed in human MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced effect by luciferase receptor gene assay	[PMID: 18921992]
Sf9	IC₅₀	15.9 1 Compound: 4, RU-58841	Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells	[PMID: 17766112]
Sf9	IC₅₀	16 1 Compound: RU-58841	Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system	[PMID: 19286380]
MDA-MB-231	IC₅₀	32 1 Compound: RU-58841	Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response	[PMID: 19286380]
MDA-MB-453	IC₅₀	31.1 1 Compound: 4, RU-58841	Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells	[PMID: 17766112]
Sf9	IC₅₀	16 1 Compound: 4, RU-58841	Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells	[PMID: 18921992]
MDA-MB-453	IC₅₀	31.1 1 Compound: 4, RU-58841	Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells	[PMID: 17766112]
MDA-MB-453	IC₅₀	40 1 Compound: 4, RU-58841	Antagonist activity against human androgen receptor expressed in human MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced effect by luciferase receptor gene assay Antagonist activity against human androgen receptor expressed in human MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced effect by luciferase receptor gene assay	[PMID: 18921992]
Sf9	IC₅₀	15.9 1 Compound: 4, RU-58841	Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells	[PMID: 17766112]
MDA-MB-231	IC₅₀	32 1 Compound: RU-58841	Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response	[PMID: 19286380]
Sf9	IC₅₀	16 1 Compound: 4, RU-58841	Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells	[PMID: 18921992]
MDA-MB-453	IC₅₀	40 1 Compound: 4, RU-58841	Antagonist activity against human androgen receptor expressed in human MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced effect by luciferase receptor gene assay Antagonist activity against human androgen receptor expressed in human MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced effect by luciferase receptor gene assay	[PMID: 18921992]
Sf9	IC₅₀	16 1 Compound: RU-58841	Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system	[PMID: 19286380]

In Vitro

RU 58841 (100 nM) inhibits DHT’s effects (agonistic effects on the wt AR) in PC3 cells with the wt AR^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RU 58841 (applied topically, 1% in ethanol) increases hair growth rates (LHGR) in balding samples grafted on to testosterone-conditioned nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

369.34

화학식

C₁₇H₁₈F₃N₃O₃

CAS No.

154992-24-2

Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=C(C=CC(N2C(C(C)(N(C2=O)CCCCO)C)=O)=C1)C#N)F

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (270.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7075 mL	13.5377 mL	27.0753 mL
5 mM	0.5415 mL	2.7075 mL	5.4151 mL
10 mM	0.2708 mL	1.3538 mL	2.7075 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.72%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (248 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice By De Brouwer, B.; Tetelin, C.; Leroy, T.; Bonfils, A.; Van Neste, D. .From British Journal of Dermatology (1997), 137(5), 699-702. [Content Brief]

[2]. Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Sch?fer-Korting M.RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia.Pharmazie. 2005 Jan;60(1):8-12. [Content Brief]

[3]. Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D.RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism.J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60. [Content Brief]

[4]. Pan HJ, et al. Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. Endocrine. 1998 Aug;9(1):39-43. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7075 mL	13.5377 mL	27.0753 mL	67.6883 mL
	5 mM	0.5415 mL	2.7075 mL	5.4151 mL	13.5377 mL
	10 mM	0.2708 mL	1.3538 mL	2.7075 mL	6.7688 mL
	15 mM	0.1805 mL	0.9025 mL	1.8050 mL	4.5126 mL
	20 mM	0.1354 mL	0.6769 mL	1.3538 mL	3.3844 mL
	25 mM	0.1083 mL	0.5415 mL	1.0830 mL	2.7075 mL
	30 mM	0.0903 mL	0.4513 mL	0.9025 mL	2.2563 mL
	40 mM	0.0677 mL	0.3384 mL	0.6769 mL	1.6922 mL
	50 mM	0.0542 mL	0.2708 mL	0.5415 mL	1.3538 mL
	60 mM	0.0451 mL	0.2256 mL	0.4513 mL	1.1281 mL
	80 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8461 mL
	100 mM	0.0271 mL	0.1354 mL	0.2708 mL	0.6769 mL

RU 58841 Related Classifications

Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RU 58841154992-24-2PSK-3841 HMR-3841RU58841RU-58841PSK3841PSK 3841HMR3841HMR 3841HMR-3841Androgen Receptorhair growthanti-androgenInhibitorinhibitorinhibit

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RU 58841 (Synonyms: PSK-3841; HMR-3841)

고객리뷰

Other Forms of RU 58841:

RU 58841 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

RU 58841 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

RU 58841 Related Classifications

Keywords:

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고객리뷰

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SAFETY DATA SHEET (SDS)

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