2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13910R
    Tenofovir (Standard) 147127-20-6 98%
    Tenofovir (Standard) is the analytical standard of Tenofovir. This product is intended for research and analytical applications. Tenofovir (GS 1278) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV).
    Tenofovir (Standard)
  • HY-139165
    AT-9010 1261253-79-5 98%
    AT-9010, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 can inhibit SARS-CoV-2 replication.
    AT-9010
  • HY-139594
    Polyketide synthase 13-IN-1 2345638-96-0 98%
    Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor.
    Polyketide synthase 13-IN-1
  • HY-139595
    Polyketide synthase 13-IN-2 2219338-48-2 98%
    Polyketide synthase 13-IN-2 (comp 42) is a polyketide synthase 13 inhibitor against Mycobacterium tuberculosis, with an MIC of 0.25 μg/mL.
    Polyketide synthase 13-IN-2
  • HY-139596
    Polyketide synthase 13-IN-3 2221801-50-7 98%
    Polyketide synthase 13-IN-3 (compound 41) is a polyketide synthase 13 inhibitor，with a MIC of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv.
    Polyketide synthase 13-IN-3
  • HY-139631
    HIV-1 inhibitor-9 2708201-36-7 98%
    HIV-1 inhibitor-9 is found to be potent inhibitor against the wild-type (WT) HIV-1 strain or multiple NNRTI-resistant strains at low nanomolar levels.
    HIV-1 inhibitor-9
  • HY-13963S
    ZCL278-13C 98%
    ZCL278-13C is a 13C-labeled version of ZCL278 (HY-13963). ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 can disrupt the interaction between Cdc42 and ITSN, and also inhibit the binding of GTP and GDP. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used in the research of arsenic neurotoxicity and HER2-positive gastric cancer (GC)[1][2][3][4].
    ZCL278-13C
  • HY-139645
    MtDTBS-IN-1 98%
    MtDTBS-IN-1 is a particularly potent binder (KD = 57 nM) and inhibitor (Ki = 5 μM) of MtDTBS.
    MtDTBS-IN-1
  • HY-139654
    α/β-Hydrolase-IN-1 2696301-42-3 98%
    α/β-Hydrolase-IN-1 exhibits the best-in-class MICs of 50 μM (25 μg/mL) and 16 μM (8.4 μg/mL) against M. smegmatis and M. tuberculosis H37Ra, respectively.
    α/β-Hydrolase-IN-1
  • HY-139657
    ThrRS-IN-2 468750-19-8 98%
    ThrRS-IN-2 is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 value of 56.5 ± 3.5 μM.
    ThrRS-IN-2
  • HY-139669
    Antifungal agent 13 2834776-94-0 98%
    Antifungal agent 13 exhibits remarkable antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.25 mg/L.
    Antifungal agent 13
  • HY-139672
    BRD5018 2245231-51-8 98%
    BRD5018 is an antimalarial agent. BRD5018 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    BRD5018
  • HY-139676
    RMG8-8 3030216-89-5 98%
    RMG8-8 shows the excellent efficacy against C. neoformans (1.56 μg/mL).
    RMG8-8
  • HY-139679
    Antibacterial agent 28 2673185-41-4 98%
    Antibacterial agent 28 is a potential antibacterial candidate for combating MRSA infections (MICs = 0.5–2 μg/mL).
    Antibacterial agent 28
  • HY-139695
    Spectinamide 1599 1620153-85-6 98%
    Spectinamide-1599 is a combination partner for anti-tuberculosis research.
    Spectinamide 1599
  • HY-139697
    HAV 3C proteinase-IN-1 1626408-58-9 98%
    HAV 3C proteinase-IN-1 is a inhibitor of Hepatitis A virus 3C proteinase.
    HAV 3C proteinase-IN-1
  • HY-139698
    GT-1 1401527-90-9 98%
    GT-1 (LCB10-0200), a siderophore-linked cephalosporin, is effective against clinical isolates of P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.
    GT-1
  • HY-139699
    GT-055 2842084-52-8 98%
    GT-055 (LCB18-055) is a novel broad-spectrum β-lactamase inhibitor.
    GT-055
  • HY-139713
    Antifungal agent 14 2710259-38-2 98%
    Antifungal agent 14 exhibits broad-spectrum activity against the fungal strains with excellent minimum inhibitory concentration values.
    Antifungal agent 14
  • HY-139721
    Tenofovir-C3-O-C15-CF3 ammonium 2611373-80-7 98%
    Tenofovir-C3-O-C15-CF3 (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo.
    Tenofovir-C3-O-C15-CF3 ammonium
Cat. No. Product Name / Synonyms Application Reactivity