GT-055
Based on 1 publication(s) in Google Scholar
GT-055 (LCB18-055) is a broad-spectrum β-lactamase inhibitor and penicillin-binding protein 2 (PBP2) inhibitor. GT-055 inactivates β-lactamase, protects GT-1 from hydrolysis, and binds tightly to PBP2, thereby inhibiting cell wall biosynthesis. GT-055 can be used for research on bacterial infections.
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- CAS No.: 2842084-52-8
- Formule: C13H20F3N5O8S
- Masse moléculaire:463.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) GT-055
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Activité biologique
Description
In Vitro
GT-055 (0.12-256 µg/mL) exhibits intrinsic antibacterial activity against E. coli panel strains with MICs of 2 to 8 µg/mL[2].
GT-055 (0.12-256 µg/mL) lacks intrinsic antibacterial activity against Acinetobacter spp. panel strains with MIC > 256 µg/mL[2].
GT-055 (0.12-256 µg/mL) exhibits intrinsic antibacterial activity against most K. pneumoniae panel strains with MICs of 2 to 8 µg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
GT-055 (20-200 mg/kg; co-administered with GT-1 at a 1:1 ratio via subcutaneous injection; once every 6 h; 7 days) combination therapy is highly effective against Y. pestis in a murine intranasal infection model, achieving 80% and 100% survival rates at doses of 60/90 mg/kg and 200/300 mg/kg, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 6-8 weeks old, infected with Burkholderia pseudomallei strain 1026b via aerosol)[1]
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Dosage:30/30 mg/kg (GT-1/GT-055, initiated 12 h post-infection); 60/60 mg/kg (GT-1/GT-055, initiated 12 h post-infection); 120/120 mg/kg (GT-1/GT-055, initiated 12 h post-infection); 120/120 mg/kg (GT-1/GT-055, initiated 6 h post-infection)
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Administration:s.c.; q6h; 21 days
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Result:Achieved 10% survival with a median survival of 10.5 days at 30/30 mg/kg.
Achieved 0% survival with a median survival of 14.5 days at 60/60 mg/kg.
Achieved 30% survival with a median survival of 42.5 days at 120/120 mg/kg initiated at 12 h post-infection.
Achieved 10% survival with a median survival of 42.5 days at 120/120 mg/kg initiated at 6 h post-infection.
Showed 0 CFU/spleen in surviving mice at 120/120 mg/kg initiated at 12 h post-infection.
Showed 1.34 × 108 CFU/spleen in one survivor at 30/30 mg/kg.
Showed 9.50 × 108 CFU/spleen in one survivor at 120/120 mg/kg initiated at 6 h post-infection.
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Animal Model:BALB/c (female, 6-8 weeks old, infected with Yersinia pestis strain CO92 via intranasal inoculation)[1]
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Dosage:20/30 mg/kg; 60/90 mg/kg; 200/300 mg/kg
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Administration:s.c.; q6h; 7 days
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Result:Resulted in 0% survival at 20/30 mg/kg.
Resulted in 80% survival at 60/90 mg/kg.
Resulted in 100% survival at 200/300 mg/kg.
Showed 0 CFU/g spleen and lung bacterial loads of 13.1 × 103, 21.1 × 103, and 0 CFU/g in 3 surviving mice at 60/90 mg/kg.
Showed 0 CFU/g spleen and lung bacterial loads of 18.7 × 103, 0, and 0 CFU/g in 3 surviving mice at 200/300 mg/kg.
Chemical Information
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CAS No. 2842084-52-8
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Masse moléculaire 463.39
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Formule C13H20F3N5O8S
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SMILES
O=C(O)C(F)(F)F.O=C1[N@]2[C@@](C3=NOC(CN)(CN)C3)([H])CC[C@@H](N1OS(=O)(O)=O)C2
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Synonyms
LCB18-055
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
2022 Apr 13;15(4):476. PMID: 35455473
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GT-055 Related Classifications
HY-139699 Related Classifications
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Keywords
- GT-055
- 2842084-52-8
- LCB18-055
- GT055
- GT 055
- Bacterial
- Beta-lactamase
- Penicillin-binding protein (PBP)
- penicillin-binding protein 2 (PBP2) inhibitor
- B. pseudomallei
- biodefense pathogens
- multidrug-resistant clinical isolates
- cell wall biosynthesis
- MDR bacteria
- E. coli
- Y. pestis
- E. cloacae
- β-lactamase inhibitor
- Inhibitor
- inhibitor
- inhibit