2842084-52-8
Chemical Structure
GT-055
Synonym(s): LCB18-055
- CAS No.: 2842084-52-8
- Formula:C13H20F3N5O8S
- Molecular Weight:463.39
IUPAC Name: 2,2,2-trifluoroacetic acid compound with (1R,2S,5R)-2-(5,5-bis(aminomethyl)-4,5-dihydroisoxazol-3-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate (1:1)
InChIKey: XGQCXSOFRKLVCG-JXLXBRSFSA-N
SMILES: O=C(O)C(F)(F)F.O=C1[N@]2[C@@](C3=NOC(CN)(CN)C3)([H])CC[C@@H](N1OS(=O)(O)=O)C2
Biological Activity: GT-055 (LCB18-055) is a broad-spectrum β-lactamase inhibitor and penicillin-binding protein 2 (PBP2) inhibitor. GT-055 inactivates β-lactamase, protects GT-1 from hydrolysis, and binds tightly to PBP2, thereby inhibiting cell wall biosynthesis. GT-055 can be used for research on bacterial infections[1][2].
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GT-055 | GT-055 (LCB18-055) is a broad-spectrum β-lactamase inhibitor and penicillin-binding protein 2 (PBP2) inhibitor. GT-055 inactivates β-lactamase, protects GT-1 from hydrolysis, and binds tightly to PBP2, thereby inhibiting cell wall biosynthesis. GT-055 can be used for research on bacterial infections. | |||||||||||||||||||||
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References
- [1]. Halasohoris SA, et al. In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens. The Journal of antibiotics. 2021 Dec;74(12):884-892. [Content Brief]
- [2]. Nguyen LP, et al. In Vitro Activity of a Novel Siderophore-Cephalosporin, GT-1 and Serine-Type β-Lactamase Inhibitor, GT-055, against Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Panel Strains. Antibiotics (Basel). 2020 May 20;9(5):267.
