2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-163042
    HSGN-218 2519410-44-5 98%
    HSGN-218 is an antibacterial agent with low Caco-2 permeability. HSGN-218 efficiently inhibits the growth of different C. difficile species with MIC values ranging from 0.007 μM to 0.07 μM.
    HSGN-218
  • HY-163044
    C12-SPM 2055647-81-7 98%
    C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases.
    C12-SPM
  • HY-163070
    Antimalarial agent 35 3054155-49-3 98%
    Antimalarial agent 35 (compound QP11) is a selective inhibitor FP2. Antimalarial agent 35 has antimalarial activity and shows synergistic effects when combined with chloroquine(HY-17589A).
    Antimalarial agent 35
  • HY-163085
    HIV capsid modulator 1 3031547-95-9 98%
    HIV capsid modulator 1(compound 21a2) is a potent HIV capsid modulator. HIV capsid modulator 1 is a quinazolin-4-one-bearing phenylalanine derivative. HIV capsid modulator 1 has antiviral activities against both HIV-1 and HIV-2.
    HIV capsid modulator 1
  • HY-163104
    Antibacterial agent 169 2879255-03-3 98%
    Antibacterial agent 169 (Compound 28) is a pyrrolamide-type GyrB/ParE inhibitor with antibacterial activity. Antibacterial agent 169 has an inhibitory effect on Gyrase and Topo IV of Staphylococcus aureus, with IC50 values of 49 nmol/L and 1.513 μmol/L respectively.
    Antibacterial agent 169
  • HY-163110
    NNRT-IN-2 2999794-78-2 98%
    NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC50 of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics.
    NNRT-IN-2
  • HY-163124
    HBV-IN-43 2305897-05-4 98%
    HBV-IN-43 (compound 5832) is a potent inhibitor of HBV.
    HBV-IN-43
  • HY-163147
    PAN endonuclease-IN-1 2378640-67-4 98%
    PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target.
    PAN endonuclease-IN-1
  • HY-163149
    AB-452 2226178-35-2 98%
    AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model.
    AB-452
  • HY-163161
    HIV-1 inhibitor-62 98%
    HIV-1 inhibitor-62 (compound 6) is an HIV-1 inhibitor that can be used in antiviral research.
    HIV-1 inhibitor-62
  • HY-163181
    MSU-43085 2810846-51-4 98%
    MSU-43085 is an orally active MmpL3 inhibitor of Mycobacterium tuberculosis (Mtb). MSU-43085 effectively inhibits Mtb in an acute murine tuberculosis infection model. MSU-43085 can be used in tuberculosis research.
    MSU-43085
  • HY-163182
    CSNK2A-IN-2 3029550-17-9 98%
    CSNK2A-IN-2 (compound 6c) is a selective CSNK2A inhibitor with antiviral activity. CSNK2A-IN-2 exhibits an inhibitory effect on viral replication and is selective for PIM3.
    CSNK2A-IN-2
  • HY-163190
    NDM-1 inhibitor-4 604811-49-6 98%
    NDM-1 inhibitor-4 (compound 27) is a NDM-1 inhibitor with Ki of 1.7 μM. NDM-1 inhibitor-4 has antimicrobial effect.
    NDM-1 inhibitor-4
  • HY-163197
    JSF-2827 3032932-67-2 98%
    JSF-2827 is a benzothiophene with antibacterial activity against Enterococcus faecium.
    JSF-2827
  • HY-163201
    TMV-IN-7 3027364-57-1 98%
    TMV-IN-7 (compound G2) is a potent inhibitor of tobacco mosaic virus (TMV). TMV-IN-7 exhibits strong hydrophobic interactions to obstructing the virus’s self-assembly.
    TMV-IN-7
  • HY-163203
    DDC18-8A 1402224-73-0 98%
    DDC18-8A is an amphiphilic dendrimer that exhibits high antibacterial and antibiofilm efficacy.
    DDC18-8A
  • HY-163284
    SDH-IN-12 3027210-28-9 98%
    SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC50s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants.
    SDH-IN-12
  • HY-163291
    AM4085 98%
    AM4085 is an orally active Antagonist for FmlH with an IC50 of 0.19 μM. AM4085 reveals metabolic stability in mouse liver microsomes and blood plasma.
    AM4085
  • HY-163292
    Antibacterial agent 180 3029324-01-1 98%
    Antibacterial agent 180 (15g), an appropriate substrate for the type I nitro reductases (TcNTR I), is a promising antitrypanosomatid agent. Antibacterial agent 180 (15g) shows nonmutagenic potential against Salmonella typhimurium strains (TA98, TA100, and TA102).
    Antibacterial agent 180
  • HY-163297
    Antifungal agent 90 3023095-87-3 98%
    Antifungal agent 90 (Compound 7n) is an antifungal agent that inhibits ergosterol biosynthesis. Antifungal agent 90 showed excellent antifungal activity against Valsa mali and Botrytis cinerea with EC50 values respectively. 4.26 and 1.41 μg/mL.
    Antifungal agent 90
Cat. No. Product Name / Synonyms Application Reactivity