2. Anti-infection
  3. Influenza Virus
  4. PAN endonuclease-IN-1

PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target.

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PAN endonuclease-IN-1 Chemical Structure

PAN endonuclease-IN-1 Chemical Structure

CAS No. : 2378640-67-4

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PAN endonuclease-IN-1 Related Antibodies

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Description

PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target[1].

IC50 & Target

Kd: 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases[1].
Molecular Weight

367.24

Formula

C14H8F3N5O4
CAS No.
SMILES

O=C(C(NC(C1=C(C(F)(F)F)C=C(C2=NN=NN2)C=C1)=C3)=C(O)C3=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PAN endonuclease-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAN endonuclease-IN-12378640-67-4Influenza Virusinfluenzaviral replicationantiviralInhibitorinhibitorinhibit

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