PAN endonuclease-IN-1
PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target.
For research use only. We do not sell to patients.
- CAS No.: 2378640-67-4
- Formula: C14H8F3N5O4
- Molecular Weight:367.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
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Biological Activity
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
>800 μM
Compound: 23
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Cytotoxicity in MDCK cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
Cytotoxicity in MDCK cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
|
[PMID: 31536340] |
| NIH3T3 | CC50 |
>800 μM
Compound: 23
|
Cytotoxicity in mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
Cytotoxicity in mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
|
[PMID: 31536340] |
Chemical Information
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CAS No. 2378640-67-4
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Molecular Weight 367.24
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Formula C14H8F3N5O4
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SMILES
O=C(C(NC(C1=C(C(F)(F)F)C=C(C2=NN=NN2)C=C1)=C3)=C(O)C3=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)