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Cat. No.: HY-163284

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SDH-IN-12

SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC₅₀s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants.

For research use only. We do not sell to patients.

CAS No.: 3027210-28-9
Formula: C₁₉H₁₃F₅N₄O₂
Molecular Weight:424.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

SDH-IN-12 Chemical Structure

CAS No.: 3027210-28-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

SDH-IN-12 (50 μM) exhibits fungicidal activities against S. sclerotiorum (98%), Alternaria solani (71%), B. cinerea (50%), R. solani (90%) and C. arachidicola (90%)^[1].
SDH-IN-12 (10 μM) destroys ultrastructure of S. sclerotiorum , resultes in contraction and obvious collapse of the mycelial surface^[1].
SDH-IN-12 reveals good bioavailability with a plasma protein binding ability (PPB) < 90%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3027210-28-9
Molecular Weight 424.32
Formula C₁₉H₁₃F₅N₄O₂
SMILES

O=C(NC1=C(C2=CC(F)=C(F)C(F)=C2)C=CC=C1)NC(C3=CN(C)N=C3C(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun NB, et al., Novel Pyrazole Acyl(thio)urea Derivatives Containing a Biphenyl Scaffold as Potential Succinate Dehydrogenase Inhibitors: Design, Synthesis, Fungicidal Activity, and SAR. J Agric Food Chem. 2024 Feb 7;72(5):2512-2525. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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