AB-452
AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model.
For research use only. We do not sell to patients.
- CAS No.: 2226178-35-2
- Formula: C21H26N2O6
- Molecular Weight:402.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | EC50 |
3 nM
Compound: (S)-20; AB-452
|
Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBeAg level measured after 16 days by ELISA
Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBeAg level measured after 16 days by ELISA
|
[PMID: 38190324] |
| Hepatocyte | EC50 |
3 nM
Compound: (S)-20; AB-452
|
Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBsAg level measured after 16 days by ELISA
Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBsAg level measured after 16 days by ELISA
|
[PMID: 38190324] |
| Hepatocyte | EC50 |
3 nM
Compound: (S)-20; AB-452
|
Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBV DNA level measured after 16 days by ELISA
Antiviral activity against AAV-Hepatitis B virus infected in human Primary hepatocyte assessed as reduction in HBV DNA level measured after 16 days by ELISA
|
[PMID: 38190324] |
| HepG2 2.2.15 | CC50 |
>50 μM
Compound: (S)-20; AB-452
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Cytotoxicity against human HepG2.2.15 cells by Cell-titer Glo luminescent assay
Cytotoxicity against human HepG2.2.15 cells by Cell-titer Glo luminescent assay
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[PMID: 38190324] |
| HepG2 2.2.15 | EC50 |
0.001 μM
Compound: (S)-20; AB-452
|
Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBsAg level incubated for 6 days by microplate-based chemiluminescence immunoassay
Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBsAg level incubated for 6 days by microplate-based chemiluminescence immunoassay
|
[PMID: 38190324] |
Chemical Information
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CAS No. 2226178-35-2
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Molecular Weight 402.44
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Formula C21H26N2O6
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SMILES
CC([C@H]1N2C(C3=NC(OC)=C(OCCCOC)C=C3C1)=CC(C(C(O)=O)=C2)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AB-452 Related Classifications
HY-163149 Related Classifications
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