2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-177299
    HCV NS5B polymerase-IN-3 1255860-45-7
    HCV NS5B polymerase-IN-3 (Compound 30a) is an inhibitor of the HCV NS5B polymerase. HCV NS5B polymerase-IN-3 exhibits anti-HCV activity in the Huh7 replicon cell line with an EC50 of 0.23 μM and shows no obvious cytotoxicity. HCV NS5B polymerase-IN-3 can be used in research related to the hepatitis C virus.
    HCV NS5B polymerase-IN-3
  • HY-177303
    AXT-914 717104-43-3 98.83%
    AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research.
    AXT-914
  • HY-177324
    Antibacterial agent 290 2163817-03-4 98%
    Antibacterial agent 290 (Compound YY), a sulfonamide derivative, is an antibacterial agent. Antibacterial agent 290 has antiproliferative activity against a variety of tumor cells. Antibacterial agent 290 significantly activates the E3 Ligase Parkin auto-ubiquitinvlation with an EC50 of 0.4 μM. Antibacterial agent 290 can used for synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordination polymers. Antibacterial agent 290 can be used for cancers, neurology disorders and infections research.
    Antibacterial agent 290
  • HY-177437
    (±)-PM 92131 124070-99-1
    (±)-PM 92131 is a non-nucleoside HIV-1 inhibitor. (±)-PM 92131 has an anti-HIV-1 activity with IC50s of 45.7 and 53.8 μM for HIV-1 RF strain in XTT cytoprotection and syncytium-forming assay, respectively. (±)-PM 92131 can be used for HIV infections research.
    (±)-PM 92131
  • HY-177540
    ent-Rhizocarpic acid 3061155-24-3
    ent-Rhizocarpic acid is an enantiomer of Rhizocarpic acid. ent-Rhizocarpic acid has more potent antibacterial and antiparasitic activity against Staphylococcus aureus (ATCC 25923) and Giardiaduodenalis 713 compared to Rhizocarpic acid. ent-Rhizocarpic acid also has a weak but selective antitumor activity against NS-1 cells.
    ent-Rhizocarpic acid
  • HY-177610
    Afovirsen 151356-08-0
    Afovirsen is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.
    Afovirsen
  • HY-177625
    Daplusiran 2202783-35-3 98%
    Daplusiran is a siRNA in JNJ-3989 (JNJ-73763989). JNJ-3989 is comprised of 2 siRNAs (Daplusiran and Tomligisiran), that target hepatitis B virus (HBV) mRNAs for degradation, thereby inhibiting HBV replication.
    Daplusiran
  • HY-177630
    Erisonersen 2834724-51-3
    Erisonersen, an antisense oligonucleotide, is a prion protein synthesis reducer. It is used for the study of Prion disease.
    Erisonersen
  • HY-177636
    GPI2A 2857819-69-1
    GPI2A is a 20-mer antisense oligonucleotide sequence that is complementary to a region of the HIV-1 gag gene. GPI2A shows a significant inhibitory effect on p55 and its cleavage product p39/41.
    GPI2A
  • HY-177637
    H5N1 aptamer sodium
    H5N1 aptamer sodium is a DNA aptamer targeted to H5N1 Avian Influenza Virus.
    H5N1 aptamer sodium
  • HY-177638
    ISIS 1082 141442-28-6
    ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro
    ISIS 1082
  • HY-177654
    Ozisiran 3061406-96-7 98%
    Ozisiran, a siRNA, is a hepatitis B virus (HBV) RNA transcript reducer with antiviral activity.
    Ozisiran
  • HY-177663
    SARSi-4 sodium 98%
    SARSi-4 sodium is a siRNA that markedly inhibited the replication of SARS-associated coronavirus (SCoV).
    SARSi-4 sodium
  • HY-177667
    Tomligisiran 2202789-48-6 98%
    Tomligisiran is a siRNA in JNJ-3989 (JNJ-73763989). JNJ-3989 is comprised of 2 siRNAs (Daplusiran and Tomligisiran), that target hepatitis B virus (HBV) mRNAs for degradation, thereby inhibiting HBV replication.
    Tomligisiran
  • HY-177670
    Zintevir 171345-51-0
    Zintevir is an antisense oligonucleotide that targets HIV-1 integrase.
    Zintevir
  • HY-177699
    Fusidic acid prodrug 3025356-77-5 98%
    Fusidic acid prodrug is an antibacterial agent. Fusidic acid prodrug has significant antibacterial activity against Pseudomonas aeruginosa (MIC = 4 µg/mL). Fusidic acid prodrug can be used in the research of infectious conditions.
    Fusidic acid prodrug
  • HY-177745
    25-Azacoprostane 37106-88-0
    25-Azacoprostane (5β-Cholan-24-dimethylamine) is an azasteroid. 25-Azacoprostane has significant inhibitory activity against the molting and metamorphosis processes of various insects. 25-Azacoprostane can be used as insecticide.
    25-Azacoprostane
  • HY-177773
    5-Hydroxymethyl flucloxacillin 75524-31-1
    5-Hydroxymethyl flucloxacillin is an active metabolite of Flucloxacillin (HY-A0246). 5-Hydroxymethyl flucloxacillin exhibits antibacterial activity.
    5-Hydroxymethyl flucloxacillin
  • HY-177784
    iDeg-3
    iDeg-3 is a selective molecular glue degrader that targets IDO1. iDeg-3 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC50 = 46 nM). iDeg-3 can be used for the researches of cancer, infection and neurological disease, such as melanoma.
    iDeg-3
  • HY-177785
    iDeg-6
    iDeg-6 is a selective molecular glue degrader that targets IDO1 with a DC50 of 6.5 nM. iDeg-6 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC50 = 1.6 μM). iDeg-6 can be used for the researches of cancer, infection and neurological disease, such as melanoma.
    iDeg-6
Cat. No. Product Name / Synonyms Application Reactivity