2. GPCR/G Protein Anti-infection
  3. CaSR SARS-CoV
  4. AXT-914

AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research.

For research use only. We do not sell to patients.

AXT-914

AXT-914 Chemical Structure

CAS No. : 717104-43-3

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Description

AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research[1][2].

Clinical Trial
Molecular Weight

487.39

Formula

C27H23BrN2O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N=C(C2=C(N1CC3=CC=C(C=C3)Br)C=CC(OCC#C)=C2)C4=CC=C(C(C)C)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (205.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0517 mL 10.2587 mL 20.5175 mL
5 mM 0.4103 mL 2.0517 mL 4.1035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0517 mL 10.2587 mL 20.5174 mL 51.2936 mL
5 mM 0.4103 mL 2.0517 mL 4.1035 mL 10.2587 mL
10 mM 0.2052 mL 1.0259 mL 2.0517 mL 5.1294 mL
15 mM 0.1368 mL 0.6839 mL 1.3678 mL 3.4196 mL
20 mM 0.1026 mL 0.5129 mL 1.0259 mL 2.5647 mL
25 mM 0.0821 mL 0.4103 mL 0.8207 mL 2.0517 mL
30 mM 0.0684 mL 0.3420 mL 0.6839 mL 1.7098 mL
40 mM 0.0513 mL 0.2565 mL 0.5129 mL 1.2823 mL
50 mM 0.0410 mL 0.2052 mL 0.4103 mL 1.0259 mL
60 mM 0.0342 mL 0.1710 mL 0.3420 mL 0.8549 mL
80 mM 0.0256 mL 0.1282 mL 0.2565 mL 0.6412 mL
100 mM 0.0205 mL 0.1026 mL 0.2052 mL 0.5129 mL
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AXT-914 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AXT-914717104-43-3AXT914AXT 914CaSRSARS-CoVCalcium-sensing receptor SARS coronavirusInhibitorCalcium-sensing receptorAntiviralHCoV 229ESARS-CoV2Calu-3 cellsBartter syndrome type 5Autosomal dominant hypocalcemiaADHCoronavirus infectionsinhibitorinhibit

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