2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W512253
    4-Hydroxyflavan 487-25-2 98%
    4-Hydroxyflavan is a hydroxyflavan that exhibits antifungal activities against sporelings of B. cinerea (ED50 = 216 μM). 4-Hydroxyflavan can be used for antifungal research.
    4-Hydroxyflavan
  • HY-W540188
    Calcium mesoxalate 21085-60-9 98%
    Calcium mesoxalate blocks HIV-1 RT (IC50: 2.2 μM).
    Calcium mesoxalate
  • HY-W540874
    1-Heptadecene 6765-39-5 98%
    1-Heptadecene is a metabolite found in Aporosa cardiosperma. 1-Heptadecene has antifungal and antibacterial activities.
    1-Heptadecene
  • HY-W588249
    Sabinene hydrate 546-79-2 98.0%
    Sabinene hydrate is a volatile organic compound of a bicyclic monoterpene alcohol. Sabinene hydrate, as a plant secondary metabolite, is naturally present in various plants and their essential oils. Sabinene hydrate exhibits broad-spectrum but varying-intensity antibacterial activity, with the greatest sensitivity to Gram-positive bacteria, especially Bacillus subtilis (MIC = 0.0312 mg/mL) and Staphylococcus aureus (MIC = 0.0625 mg/mL). Sabinene hydrate also shows certain sensitivity to Escherichia coli and Candida albicans, with MIC values of 0.125 mg/mL for both. Sabinene hydrate can be used in the research of the ecological functions of plant defense substances.
    Sabinene hydrate
  • HY-W588257
    (+)-Thienamycin 59995-64-1 98%
    (+)-Thienamycin is a potent broad-spectrum antibacterial and β-lactamase inhibitor that can be from Streptomyces cattleya.
    (+)-Thienamycin
  • HY-W616426
    3,3'-Bi[1H-indole] 13637-37-1
    3,3'-Bi[1H-indole] is a MtbFtsZ inhibitor. 3,3'-Bi[1H-indole] inhibits the GTPase activity of MtbFtsZ. 3,3'-Bi[1H-indole] increases the cell length of Mycobacterium smegmatis and Bacillus subtilis. 3,3'-Bi[1H-indole] can be used in the research of tuberculosis.
    3,3'-Bi[1H-indole]
  • HY-W653871
    Florfenicol amine-d3 3023974-39-9 98%
    Florfenicol amine-d3 is deuterated labeled Florfenicol amine. Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases.
    Florfenicol amine-d3
  • HY-W653905
    Amantadine-d15 hydrochloride 98%
    Amantadine-d15 hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.
    Amantadine-d15 hydrochloride
  • HY-W653961
    Tenofovir alafenamide-d5 fumarate 98%
    Tenofovir alafenamide-d5 fumarate (GS-7340-d5 fumarate) is the deuterium labeled Tenofovir alafenamide fumarate (HY-15232A). Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
    Tenofovir alafenamide-d5 fumarate
  • HY-W654234
    Hydroxyphenyllactic acid-d3 2249814-89-7 98%
    Hydroxyphenyllactic acid-d3 is the deuterium labeled Hydroxyphenyllactic acid (HY-113219). Hydroxyphenyllactic acid is an antifungal metabolite.
    Hydroxyphenyllactic acid-d3
  • HY-W654247
    Lamivudine-13C,d2 2714473-70-6 98%
    Lamivudine-13C,d2 is the deuterium labeled and 13C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
    Lamivudine-13C,d2
  • HY-W654302
    Oseltamivir-fructosyl 2413185-85-8 98%
    Oseltamivir-fructosyl exhibits antiviral activity against influenza viruses and has inhibitory effects on various types of bacteria such as streptococcus and serratia marcescens.
    Oseltamivir-fructosyl
  • HY-W658295
    2-Ethoxypentane 1817-89-6 98%
    2-Ethoxypentane is an active ingredient that can be extracted from Rubus corchorifolius. 2-Ethoxypentane is a volatile component with antibacterial activity. 2-Ethoxypentane can be studied through bacterial infection.
    2-Ethoxypentane
  • HY-W660701
    Bamipine 4945-47-5 98%
    Bamipine is a potent histamine H1-receptor antagonist. Bamipine exhibits moderate activity against Mycobacterium tuberculosis. Bamipine has a mild sedative effect.
    Bamipine
  • HY-W663179
    DNDI-VL-2098 681492-17-1 98%
    DNDI-VL-2098 is an orally active antileishmanial agent. DNDI-VL-2098 exhibits high permeability, in vitro metabolic stability, and selective inhibition of CYP2C19 (IC50=0.47 μM). DNDI-VL-2098 does not affect the activities of other major CYP enzymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A4) at concentrations up to 12.5 μM. It shows favorable pharmacokinetic properties in multiple animal models including mice, hamsters, rats and dogs. DNDI-VL-2098 is characterized by moderate to high plasma protein binding and can be used for the research of visceral leishmaniasis.
    DNDI-VL-2098
  • HY-W663230
    Eugenitin 480-12-6 98%
    Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD50=39.9 μM. Eugenitin has low cytotoxicity (IC50 >131 μM) against several human cancer cell lines.
    Eugenitin
  • HY-W665208
    Zapotin 14813-19-5 98%
    Zapotin is a member of the polymethoxyflavones, which are natural polyphenols from the group of flavonoid. Zapotin exhibits antidepressant, anticancer, antifungal, and antioxidant activity. Zapotin is a chemopreventive and chemotherapeutic agent. Zapotin can result in a reduction of large aberrant crypt foci in CF-1 mouse model. Zapotin inhibits autophagosome formation. Zapotin has inhibitory activity in mouse mammary organ culture with an IC50 of 50 µg/mL.
    Zapotin
  • HY-W665882
    Norketotifen 34580-20-6 98%
    Norketotifen is the active metabolite of Ketotifen (HY-B0157). Norketotifen exhibits skin anti-inflammatory activity, anti-malarial activity, and antipruritic activity against non-histamine-mediated dog itching in mice. Norketotifen effectively inhibits TNF-α release without causing any sedative side effects. Norketotifen can be used for research on non-sedating anti-inflammatory agents.
    Norketotifen
  • HY-W671129
    Frenolicin B 68930-68-7 98%
    Frenolicin B is a covalent enzyme inhibitor and an orally active antiparasitic agent, with an IC50 of 0.2 μM against human Prx1. Frenolicin B selectively inhibits Glutaredoxin 3 via covalent modification of the active-site cysteines Cys159/Cys261. Frenolicin B selectively inhibits Peroxiredoxin 1 via covalent modification of the active-site cysteines Cys83/Cys173. Frenolicin B can be used in research related to colon cancer, breast cancer, lung cancer and malaria.
    Frenolicin B
  • HY-W673618
    Hycanthone aldehyde 3613-13-6 98%
    Hycanthone aldehyde (XII) is a thioxanthone derivative of lucanthone that exhibits anti-tapeworm activity and potential anticancer activity.
    Hycanthone aldehyde
Cat. No. Product Name / Synonyms Application Reactivity