3,3'-Bi[1H-indole]
3,3'-Bi[1H-indole] is a MtbFtsZ inhibitor. 3,3'-Bi[1H-indole] inhibits the GTPase activity of MtbFtsZ. 3,3'-Bi[1H-indole] increases the cell length of Mycobacterium smegmatis and Bacillus subtilis. 3,3'-Bi[1H-indole] can be used in the research of tuberculosis.
For research use only. We do not sell to patients.
- CAS No.: 13637-37-1
- Formula: C16H12N2
- Molecular Weight:232.29
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
3,3'-Bi[1H-indole] (compound I5) inhibits the growth of Mycobacterium smegmatis mc2155 at 48 h, with an MIC of 62.5 μg/mL[1].
3,3'-Bi[1H-indole] (5 d) inhibits the growth of Mycobacterium tuberculosis H37Rv with an MIC of 150 μg/mL[1].
3,3'-Bi[1H-indole] (20 μM; 24 h) inhibits the proliferation rate of HeLa cells[11].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Resulted in 63.5 ± 3.0% cell proliferation (viability) relative to untreated control cells.
Chemical Information
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CAS No. 13637-37-1
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Appearance Solid
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Molecular Weight 232.29
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Formula C16H12N2
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SMILES
C=1C=CC2=C(C1)NC=C2C3=CNC=4C=CC=CC43
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)