2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N8497
    Leoidin 105350-54-7 98%
    Leoidin is an OATP1B1 and OATP1B3 inhibitor with Ki values of 0.08 and 1.84 μM，respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC50= 42 μM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides.
    Leoidin
  • HY-N8504
    Neoaureothin 59795-94-7 98%
    Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50=13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50=1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.
    Neoaureothin
  • HY-N8511
    Acremine I 1110661-29-4 98%
    Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew.
    Acremine I
  • HY-N8519
    Urdamycin B 104542-46-3 98%
    Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections.
    Urdamycin B
  • HY-N8520
    Variculanol 135513-21-2 98%
    Variculanol is an antimicrobial, anticancer and anti-HCV NS3/4A Protease agent which can be extracted from marine fungus Aspergillus versicolor.
    Variculanol
  • HY-N8535
    Massarigenin C 496926-08-0 98%
    Massarigenin C is a compound that can be isolated from Massarina tunicata. Massarigenin C has inhibitory activity against Bacillus subtilis (ATCC 6051).
    Massarigenin C
  • HY-N8691
    2',6'-Dihydroxy-4'-methoxydihydrochalcone 35241-55-5 98%
    2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro.
    2',6'-Dihydroxy-4'-methoxydihydrochalcone
  • HY-N8849
    4-Methyl-6,7-methylenedioxycoumarin 15071-04-2 98%
    4-Methyl-6,7-methylenedioxycoumarin (4-Methylayapin) is a Coumarin (HY-N0709) derivative. 4-Methyl-6,7-methylenedioxycoumarin exhibits antifungal activity against Pythium sp..
    4-Methyl-6,7-methylenedioxycoumarin
  • HY-N8908
    2α,9α,11-Trihydroxy-6-oxodrim-7-ene 1175543-03-9 98%
    2α,9α,11-Trihydroxy-6-oxodrim-7-ene is a natural product that can be isolated from the culture medium of the marine-derived fungus Aspergillus insuetus.
    2α,9α,11-Trihydroxy-6-oxodrim-7-ene
  • HY-N8921
    Methoxyanigorufone 56252-05-2 98%
    Methoxyanigorufone (compound 4) is a compound that can be isloated from Musa acuminata var. "Yangambi km 5".
    Methoxyanigorufone
  • HY-N9112
    Eriodictyol 7, 3'-dimethyl ether 54352-60-2 98%
    Eriodictyol 7, 3'-dimethyl ether (compound 11) is the first flavonoid extract from B. riparia with antioxidant and antibacterial activity.
    Eriodictyol 7, 3'-dimethyl ether
  • HY-N9220
    6-Epi-albassitriol 178456-58-1 98%
    6-Epi-albassitriol can be isolated from Aspergillus sp. FH-A 6357. 6-Epi-albassitriol inhibits the cholesterol synthesis with an inhibition rate of 40% at a concentration of 10 nM in HepG2. 6-Epi-albassitriol exhibits antiviral activity against influenza A virus and parainfluenza virus with MIC of 44.4-133.3 µg/mL.
    6-Epi-albassitriol
  • HY-N9464
    Episterol 474-68-0 98%
    Episterol is an Ergosterol (HY-N0181) biosynthetic intermediate. Episterol replaces Ergosterol as the major sterol in Saccharomyces cerevisiae Δerg3 mutants, confers resistance to combined lethal and vacuole-disruptive actions of Amphotericin B (HY-B0221) and MC12 (HY-175024).
    Episterol
  • HY-N9477
    Betulinic aldehyde oxime 25613-12-1 98%
    Betulinic aldehyde oxime (Compound 31) is a betulin (HY-N0083) derivative that has antimicrobial properties against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans. Betulinic aldehyde oxime displays cytotoxicity towards hepatocytes, with an IC50 of 25 μM.
    Betulinic aldehyde oxime
  • HY-N9495
    (-)-trans-Myrtanol 53369-17-8 98.73%
    (-)-trans-Myrtanol is an antimicrobial and acaricide agent. (-)-trans-Myrtanol exhibits potent antimicrobial activities against harmful intestinal bacteria. (-)-trans-Myrtanol shows acaricidal activities for D. farinae, D. pteronyssinus, T. putrescentiae with LD50 values of 2.30 µg/cm2, 2.22 µg/cm2, 12.95 µg/cm2, respectively.
    (-)-trans-Myrtanol
  • HY-N9552
    Purpactin A 133806-59-4 98%
    Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor found in Pen. Purpurogenum FO-6.
    Purpactin A
  • HY-N9573
    Zinniol 17811-28-8 98%
    Zinniol is a penta-substituted benzene phytotoxin that can be produced by a variety of phytopathogenic fungi. Zinniol can be detected in sunflower tissues in the early stage of infection and may be involved in the occurrence of sunflower diseases.
    Zinniol
  • HY-N9709
    5-Hydroxysophoranone 90686-12-7 98%
    5-Hydroxysophoranone is a flavanone that can be isolated from the Erythrina subumbrans. 5-Hydroxysophoranone shows weak antibacterial activity against several strains of Streptococcus.
    5-Hydroxysophoranone
  • HY-N9720
    Herbarin 36379-67-6 98%
    Herbarin is a quinone antibiotic. Herbarin complex has anti-Gram-positive bacteria, negative bacteria, Citrus Canker xanthomonas, potato early blight, Aspergillus Niger, Decaprous and other fungal activities.
    Herbarin
  • HY-N9754
    Cyclosporin L 108027-39-0 98%
    Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities.
    Cyclosporin L
Cat. No. Product Name / Synonyms Application Reactivity