2. Others Anti-infection
  3. Drug Intermediate Fungal
  4. Episterol

Episterol is an Ergosterol (HY-N0181) biosynthetic intermediate. Episterol replaces Ergosterol as the major sterol in Saccharomyces cerevisiae Δerg3 mutants, confers resistance to combined lethal and vacuole-disruptive actions of Amphotericin B (HY-B0221) and MC12 (HY-175024).

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Episterol

Episterol Chemical Structure

CAS No. : 474-68-0

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Episterol Related Antibodies

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Description

Episterol is an Ergosterol (HY-N0181) biosynthetic intermediate. Episterol replaces Ergosterol as the major sterol in Saccharomyces cerevisiae Δerg3 mutants, confers resistance to combined lethal and vacuole-disruptive actions of Amphotericin B (HY-B0221) and MC12 (HY-175024)[1].

In Vitro

Episterol accumulation in Saccharomyces cerevisiae Δerg3 mutant cells eliminates the synergistic antifungal activity between Amphotericin B (HY-B0221) and MC12 (HY-175024), resulting in an indifferent drug interaction with an FIC index of 2.00[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Episterol Related Antibodies
Molecular Weight

398.68

Formula

C28H46O
CAS No.
SMILES

C[C@@]12[C@](C=3[C@@]([C@]4(C)[C@@](CC3)(C[C@@H](O)CC4)[H])(CC1)[H])(CC[C@@]2([C@@H](CCC(C(C)C)=C)C)[H])[H]
Structure Classification
Initial Source

Saccharomyces cerevisiae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Episterol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Episterol474-68-0Drug IntermediateFungalDrug Iintermediatepotassium ion effluxergosterolpotassium-permeable channelsSaccharomyces cerevisiae Δerg3 mutantsfungal plasma membranesamphotericin Bvacuolar membranesN-methyl-N'-dodecylguanidinevacuole morphologyInhibitorinhibitorinhibit

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