2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-121613
    Resistoflavine 29706-96-5 98%
    Resistoflavine is a metabolite of the marine actinomycete S. chibaensis. It slows the growth of and is cytotoxic to HMO2 and HepG2 cells with mean lethal concentrations (LC50) of 0.013 and 0.016 μg/mL, respectively.
    Resistoflavine
  • HY-121633
    Kayahope 49828-25-3 98%
    Kayahope is a fungal inhibitor.
    Kayahope
  • HY-121718
    DQBS 372087-80-4 98%
    DQBS can bind to HIV-1 nef protein, and inhibits Nef-dependent HIV replication.
    DQBS
  • HY-121763
    SCH-43478 112446-99-8 98%
    SCH-43478 is a non-nucleoside antiviral agent. SCH-43478 shows potent and selective activity against herpes simplex virus type 2 (HSV-2) with an IC50 of 1.8 μg/mL using Vero cells. SCH-43478 demonstrates significant efficacy in the guinea pig genital model of HSV infection.
    SCH-43478
  • HY-121766
    Iprovalicarb 140923-17-7 98%
    Iprovalicarb (Fencaramid; SZX-0722) is a fungicide that can be used for the study of fungal diseases in the wine sector.
    Iprovalicarb
  • HY-121785
    10-Thiofolic acid 54931-98-5 98%
    10-Thiofolic acid is a potent antibacterial and antitumor agent. 10-Thiofolic acid inhibits the growth of Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469). 10-Thiofolic acid has the potential for the research of leukemia.
    10-Thiofolic acid
  • HY-121817
    Sulfiram 95-05-6
    Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease.
    Sulfiram
  • HY-121909
    Piperic acid 136-72-1 99.43%
    Piperic acid is a natural antioxidant and antibacterial agent. Piperic acid can be used in food preservation and human health.
    Piperic acid
  • HY-122018
    GS-9148 875608-25-6 98%
    GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC50 value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation.
    GS-9148
  • HY-122035
    Flambalactone 55729-17-4 98%
    Flambalactone is a degradation product formed by methanolysis of the antibiotic flambamycin.
    Flambalactone
  • HY-122058
    KRH-3955 1097732-62-1 98%
    KRH-3955 is a CXCR4 antagonist with good bioavailability and potent anti-HIV-1 activity. KRH-3955 can effectively inhibit the replication of X4 HIV-1, including clinical isolates from different donors. KRH-3955 also shows activity against recombinant X4 HIV-1 containing reverse transcriptase, protease and tyrosinase resistance mutations. KRH-3955 can inhibit the binding of SDF-1alpha to CXCR4 and calcium ion signaling through this receptor. KRH-3955 inhibits the binding of an antibody against CXCR4 to CXCR4, showing a potent antagonistic effect on CXCR4. KRH-3955 shows an oral bioavailability of 25.6% in rats and can inhibit the replication of X4 HIV-1 in vivo.
    KRH-3955
  • HY-122073
    Furalazine 556-12-7 98%
    Furalazine is an antimicrobial agent. Furalazine shows activity against drug-resistant strains of cholera bacteria. Furalazine has the potential for the research of cholera.
    Furalazine
  • HY-122089
    Lapyrium 109260-82-4 98%
    Lapyrium is a broad-spectrum antimicrobial surfactant.
    Lapyrium
  • HY-122174
    ME-1036 432038-96-5 98%
    ME-1036 (CP-5609) is a carbapenem antibiotic. ME-1036 against resistant Gram-positive organisms, including Methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococci (VRE), and ESBL-producing E. coli and K. pneumoniae but is not effective against P. aeruginosa.
    ME-1036
  • HY-122256
    L-870812 410545-90-3 98%
    L-870812 is a HIV-1 integration with integrase strand transfer inhibitor. L-870812 consistently blocks cell-free and cell-associated HIV-1 infection. L-870812 blocks subtype C and CRFO2_AG primary isolates. L-870812 can be used for the study of replication-deficient HIV-1 Ba-L (env) pseudovirus.
    L-870812
  • HY-122260
    S-25932 92358-02-6 98%
    S-25932 is a potent 4-quinolones antibacterial agent. S-25932 shows broad gram-negative antibacterial activity. S-25932 shows inhibition for Enterobacter aerogenes, Enterobacter addlomerans, Enterobacter coloacae, Escherichia coli with MIC90 values of 1.0, 2.0, 1.0, 0.25 µg/mL, respectively.
    S-25932
  • HY-122274
    MMV666693 312527-99-4 98%
    MMV666693 is a translation inhibitor specific for Plasmodium falciparum. MMV666693 has low cytotoxicity in human fibroblasts (IC50>32 µM) and can be used in the development of antimalarial drugs.
    MMV666693
  • HY-122284
    CP-5068 352305-79-4 98%
    CP-5068is a cell wall inhibitor that can be used for the study of infectious diseases.
    CP-5068
  • HY-122288
    SC 28538 64444-68-4 98%
    SC 28538 is a compound with antimicrobial activity. SC 28538 exerts its antimicrobial effect by reducing its nitro moiety in an anaerobic environment to form cytotoxic free radicals that can damage DNA and other key biomolecules of microorganisms.
    SC 28538
  • HY-122327
    Nodusmicin 76265-48-0 98%
    Nodusmicin is a macrolide antibiotic against antibiotic-susceptible and -resistant S. aureus with MIC values of 125, 250 and 250 μg/mL for UC-76, UC-6685, and UC-6690 strains, respectively.
    Nodusmicin
Cat. No. Product Name / Synonyms Application Reactivity