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Cat. No.: HY-122018

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GS-9148

GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC₅₀ value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation.

For research use only. We do not sell to patients.

CAS No.: 875608-25-6
Formula: C₁₀H₁₁FN₅O₅P
Molecular Weight:331.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

GS-9148 Chemical Structure

CAS No.: 875608-25-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Classifications
Bioz

Biological Activity

Description

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	CC₅₀	182 μM Compound: GS-9148	Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
CHO	CC₅₀	≥4.5 μM Compound: GS-9148	Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
CHO	CC₅₀	≥95 μM Compound: GS-9148	Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
MT2	EC₅₀	12.3 μM Compound: 1, GS-9148, 2'-Fd4AP	Antiviral activity against HIV1 3B in MT2 cells Antiviral activity against HIV1 3B in MT2 cells	[PMID: 18082402]
MT2	CC₅₀	>1000 μM Compound: 1, GS-9148, 2'-Fd4AP	Cytotoxicity against human MT2 cells Cytotoxicity against human MT2 cells	[PMID: 18082402]
MT2	EC₅₀	12.3 μM Compound: 4, 2'-Fd4AP	Antiviral activity against wild type HIV1 3B in MT2 cells Antiviral activity against wild type HIV1 3B in MT2 cells	[PMID: 18164198]
MT2	IC₅₀	1.9 μM Compound: 4, 2'-Fd4AP	Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells	[PMID: 18164198]
MT2	CC₅₀	>1000 μM Compound: 4, 2'-Fd4AP	Cytotoxicity against human MT2 cells Cytotoxicity against human MT2 cells	[PMID: 18164198]
MT2	EC₅₀	12 μM Compound: 3, GS-9148	Antiviral activity against HIV1 3a infected human MT2 cells assessed as inhibition of viral-induced cytopathic effect after 3 days by XTT assay Antiviral activity against HIV1 3a infected human MT2 cells assessed as inhibition of viral-induced cytopathic effect after 3 days by XTT assay	[PMID: 19179082]
MT2	CC₅₀	>1000 μM Compound: 3, GS-9148	Cytotoxicity against human MT2 cells after 5 days Cytotoxicity against human MT2 cells after 5 days	[PMID: 19179082]
MT2	EC₅₀	10600 nM Compound: 4, 2'-Fd4AP, GS-9148	Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by XTT assay Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by XTT assay	[PMID: 20409721]
MT2	CC₅₀	>100000 nM Compound: 4, 2'-Fd4AP, GS-9148	Cytotoxicity against human MT2 cells after 5 days by XTT assay Cytotoxicity against human MT2 cells after 5 days by XTT assay	[PMID: 20409721]

Chemical Information

CAS No. 875608-25-6
Molecular Weight 331.20
Formula C₁₀H₁₁FN₅O₅P
SMILES

OP(O)(CO[C@H]1O[C@H](C(F)=C1)N2C=NC3=C(N=CN=C23)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cihlar T, et al. Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131. Antimicrob Agents Chemother. 2008 Feb;52(2):655-65. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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GS-9148

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GS-9148 Related Classifications

HY-122018 Related Classifications