875608-25-6
875608-25-6
Chemical Structure
GS-9148
- CAS No.: 875608-25-6
- Formula:C10H11FN5O5P
- Molecular Weight:331.20
IUPAC Name: ((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)phosphonic acid
InChIKey: MPSGQQOHTJUJKB-QUBYGPBYSA-N
SMILES: OP(O)(CO[C@H]1O[C@H](C(F)=C1)N2C=NC3=C(N=CN=C23)N)=O
Biological Activity: GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC50 value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation[1].
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GS-9148 | GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC50 value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation. | |||||||||||||||||||||
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