2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7314
    Asebogenin 520-42-3 98%
    Asebogenin has antimalarial activity in vitro. Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps.
    Asebogenin
  • HY-N7316
    Frangulin B 14101-04-3 98%
    Frangulin B, a natural compound that can be isolated from Rhamnus formosana, is an antagonist of collagen-induced platelet aggregation and adhesion.
    Frangulin B
  • HY-N7324
    Dehydroperilloxin 263241-09-4 98%
    Dehydroperilloxin is a natural compound isolated from the dichloromethane extract of the stems of Perilla frutescens var. acuta. Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC50 value of 30.4 μM.
    Dehydroperilloxin
  • HY-N7491
    Verticilide 693778-57-3 98%
    Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 μM (whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9 μM)).
    Verticilide
  • HY-N7518
    Eulophiol 87402-72-0 98%
    Eulophiol shows the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity with an EC50 of 27.7μM. Antioxidant activity.
    Eulophiol
  • HY-N7679
    Stachyanthuside A 864779-30-6 98%
    Stachyanthuside A is an ellagic acid glycoside isolated from the leaves of Diplopanax stachyanthus.
    Stachyanthuside A
  • HY-N7733
    Fasciculic acid A 126906-00-1 98%
    Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
    Fasciculic acid A
  • HY-N7785
    N-Demethyl-α-obscurine 34399-44-5 98%
    N-Demethyl-α-obscurine, a lycodine-type Lycopodium alkaloid, is isolated from Lycopodii Herba.
    N-Demethyl-α-obscurine
  • HY-N7851
    Terpineol 8000-41-7
    Terpineol is a monoterpenoid alcohol compound that is widely found in plants, especially in the peels of citrus fruits. Terpineol has antioxidant, anti-inflammatory and antibacterial activities and is commonly used in the fragrance industry as an additive in food, beverages, cosmetics and perfumes.
    Terpineol
  • HY-N7937
    γ-Asarone 5353-15-1 99.36%
    γ-Asarone, a phenylpropene, shows strong correlation with the biological activities (anti-oxidative, anti-inflammatory and neurotrophic effects).
    γ-Asarone
  • HY-N7945
    6-Hydroxykaempferol 3-O-β-rutinoside-6-O-β-D-glucoside 145134-63-0 98%
    6-Hydroxykaempferol 3-O-β-rutinoside-6-O-β-D-glucoside is a potent antioxidant that can be isolated from Carthamus tinctorius.
    6-Hydroxykaempferol 3-O-β-rutinoside-6-O-β-D-glucoside
  • HY-N8085
    Icariside F2 115009-57-9 98%
    Icariside F2 is a potent NF-κB inhibitor with an IC50 value of 16.25 μM. Icariside F2 is an aromatic glycoside isolated from the leaves of E. ulmoides Oliver. Icariside F2 has anti-inflammatory activity.
    Icariside F2
  • HY-N8096
    Raddeanoside R17 824401-07-2 98%
    Raddeanoside R17 (Pulchinenoside E3) is a saponin compound that can be isolated from the root of Pulsatilla koreana. Raddeanoside R17 shows anti-inflammatory effects.
    Raddeanoside R17
  • HY-N8160
    Dehydrocurdione 38230-32-9
    Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity.
    Dehydrocurdione
  • HY-N8209
    (+)-Medioresinol Di-O-β-D-glucopyranoside 88142-63-6 98.99%
    (+)-Medioresinol Di-O-β-D-glucopyranoside is a lignan glucoside with strong inhibitory activity of 3', 5'-cyclic monophosphate (cyclic AMP) phosphodiesterase.
    (+)-Medioresinol Di-O-β-D-glucopyranoside
  • HY-N8229
    7β,15α,20-Trihydroxy-3,11,23-trioxo-5α-lanosta-8-en-26-oic acid 2374206-89-8 98%
    7β,15α,20-Trihydroxy-3,11,23-trioxo-5α-lanosta-8-en-26-oic acid is a triterpenoid compound found in Ganoderma lucidum. 7β,15α,20-Trihydroxy-3,11,23-trioxo-5α-lanosta-8-en-26-oic acid may exhibit anti-inflammatory activity and holds potential for research in inflammatory diseases.
    7β,15α,20-Trihydroxy-3,11,23-trioxo-5α-lanosta-8-en-26-oic acid
  • HY-N8304
    Shegansu B 291535-65-4 98%
    Shegansu B is an inhibitor of IL-1β. Shegansu B 6 inhibits IL-1β expression on LPS-induced THP-1 cells with 64.74% inhibition. Shegansu B has anti-inflammatory activity.
    Shegansu B
  • HY-N8372
    Nalanthalide 145603-76-5 98%
    Nalanthalide is a voltage-gated potassium channel Kv1.3 blocker (IC50=3.9 µM) and a potential immunosuppressant. Nalanthalide can be used for research on inflammatory immune diseases, such as neuroinflammation.
    Nalanthalide
  • HY-N8380
    (-)-Latifolin 10154-42-4 98%
    (-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities.
    (-)-Latifolin
  • HY-N8541
    Endocrocin 481-70-9 98%
    Endocrocin, an anthraquinone, is a fungal secondary metabolite. Endocrocin is a potent chemotaxis inhibitor with immunosuppressive properties.
    Endocrocin
Cat. No. Product Name / Synonyms Application Reactivity