2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-186199
    α-Glucosidase-IN-117 2410538-77-9
    α-Glucosidase-IN-117 is a low-activity α-glucosidase (α-glucosidase) inhibitor belonging to the coumarin derivative class, with an inhibition rate of 19.51% at 100 μM. α-Glucosidase-IN-117 can be used in diabetes research.
    α-Glucosidase-IN-117
  • HY-18620R
    DZ2002 (Standard) 33231-14-0
    DZ2002 (Standard) is the analytical standard of DZ2002. This product is intended for research and analytical applications. DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis.
    DZ2002 (Standard)
  • HY-186223
    Enzyme modulator-1 897375-76-7 98%
    Enzyme modulator-1 (example 205) is a potent enzyme modulator that modulates p38, bcr-ab1, and VEGFR. Enzyme modulator-1 can be used for the research of cancer, rheumatoid arthritis, retinopathies including diabetic retinal neuropathy and macular degeneration.
    Enzyme modulator-1
  • HY-18731R
    1400W Dihydrochloride (Standard) 214358-33-5 98%
    1400W (Dihydrochloride) (Standard) is the analytical standard of 1400W (Dihydrochloride). This product is intended for research and analytical applications. 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation.
    1400W Dihydrochloride (Standard)
  • HY-18758R
    IN-1130 (Standard) 868612-83-3 98%
    IN-1130 (Standard) is the analytical standard of IN-1130. This product is intended for research and analytical applications. IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis.
    IN-1130 (Standard)
  • HY-19017B
    Fenclozine dimaleate 76823-82-0 98%
    Fenclozine dimaleate is a non-steroidal antiinflammatory agent.
    Fenclozine dimaleate
  • HY-19151B
    Fuzapladib potassium 141284-74-4 98%
    Fuzapladib (IS-741) potassium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib potassium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib potassium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
    Fuzapladib potassium
  • HY-19317R
    ITE (Standard) 448906-42-1 98%
    ITE (Standard) is the analytical standard of ITE. This product is intended for research and analytical applications. ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.
    ITE (Standard)
  • HY-19344R
    Lifitegrast (Standard) 1025967-78-5 98%
    Lifitegrast (Standard) is the analytical standard of Lifitegrast. This product is intended for research and analytical applications. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
    Lifitegrast (Standard)
  • HY-19344S
    Lifitegrast-d4 98%
    Lifitegrast-d4 (SAR 1118-d4) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
    Lifitegrast-d4
  • HY-19384R
    Enflicoxib (Standard) 251442-94-1 98%
    Enflicoxib (Standard) is the analytical standard of Enflicoxib. This product is intended for research and analytical applications. Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models.
    Enflicoxib (Standard)
  • HY-19440R
    Esonarimod (Standard) 101973-77-7 98%
    Esonarimod (Standard) is the analytical standard of Esonarimod. This product is intended for research and analytical applications. Esonarimod (KE-298) is an antirheumatic agent.
    Esonarimod (Standard)
  • HY-19562A
    PF-06260933 hydrochloride 1883548-86-4 99.42%
    PF-06260933 hydrochloride is the hydrochloride form of PF-06260933 (HY-19562). PF-06260933 hydrochloride is an orally active and highly selective inhibitor of MAP4K4 with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
    PF-06260933 hydrochloride
  • HY-19657R
    Oxypurinol (Standard) 2465-59-0 98%
    Oxypurinol (Standard) is the analytical standard of Oxypurinol. This product is intended for research and analytical applications. Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
    Oxypurinol (Standard)
  • HY-19693R
    Cariporide (Standard) 159138-80-4 98%
    Cariporide (Standard) is the analytical standard of Cariporide. This product is intended for research and analytical applications. Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.
    Cariporide (Standard)
  • HY-19883R
    Lusutrombopag (Standard) 1110766-97-6 98%
    Lusutrombopag (Standard) is the analytical standard of Lusutrombopag. This product is intended for research and analytical applications. Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.
    Lusutrombopag (Standard)
  • HY-21075R
    3-Furanoic acid (Standard) 488-93-7 98%
    3-Furanoic acid (Standard) is the analytical standard of 3-Furanoic acid. This product is intended for research and analytical applications. 3-Furanoic acid is an active unit, and its derivatives have a wide range of anti-inflammatory activities. 3-Furanoic acid-related derivatives can target inflammation-related signaling pathways and inhibit the proliferation of synovial fibroblasts to exert immunomodulatory effects.
    3-Furanoic acid (Standard)
  • HY-24470B
    1-(9H-Fluoren-9-yl)ethanol 3023-49-2 98%
    1-(9H-Fluoren-9-yl)ethanol is a prominent fragment in β-lactam antibiotic modification and an important building block for anti-inflammatory agent.
    1-(9H-Fluoren-9-yl)ethanol
  • HY-30151R
    Methoxsalen (Standard) 298-81-7 98%
    Methoxsalen (Standard) is the analytical standard of Methoxsalen. This product is intended for research and analytical applications. Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.
    Methoxsalen (Standard)
  • HY-32337R
    Tacalcitol (Standard) 57333-96-7
    Tacalcitol (Standard) is the analytical standard of Tacalcitol. This product is intended for research and analytical applications. Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases.
    Tacalcitol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity