Sauristolactam (Synonyms: Saurolactam)

Cat. No.: HY-118482: Ficha de datos Instrucciones de manejo
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Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation.

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Sauristolactam Estructura química

No. CAS : 128533-02-8

Tamaño	Stock
5 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
25 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31

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Descripciòn

Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells^[1]. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-15	GI₅₀	4.1 3 Compound: 10	Antiproliferative activity against human HCT15 cells by SRB assay Antiproliferative activity against human HCT15 cells by SRB assay	[PMID: 19394218]
HCT-15	GI₅₀	4.1 3 Compound: 10	Antiproliferative activity against human HCT15 cells by SRB assay Antiproliferative activity against human HCT15 cells by SRB assay	[PMID: 19394218]
HCT-15	GI₅₀	4.1 3 Compound: 10	Antiproliferative activity against human HCT15 cells by SRB assay Antiproliferative activity against human HCT15 cells by SRB assay	[PMID: 19394218]
HCT-15	GI₅₀	4.38 3 Compound: 10	Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay	[PMID: 19394218]
HCT-15	GI₅₀	4.38 3 Compound: 10	Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay	[PMID: 19394218]
HCT-15	GI₅₀	4.38 3 Compound: 10	Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay	[PMID: 19394218]
MES-SA	GI₅₀	23.75 3 Compound: 10	Antiproliferative activity against human MESSA cells by SRB assay Antiproliferative activity against human MESSA cells by SRB assay	[PMID: 19394218]
MES-SA	GI₅₀	23.75 3 Compound: 10	Antiproliferative activity against human MESSA cells by SRB assay Antiproliferative activity against human MESSA cells by SRB assay	[PMID: 19394218]
MES-SA	GI₅₀	23.75 3 Compound: 10	Antiproliferative activity against human MESSA cells by SRB assay Antiproliferative activity against human MESSA cells by SRB assay	[PMID: 19394218]
MES-SA/Dx5	GI₅₀	23.11 3 Compound: 10	Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay	[PMID: 19394218]
MES-SA/Dx5	GI₅₀	23.11 3 Compound: 10	Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay	[PMID: 19394218]
MES-SA/Dx5	GI₅₀	23.11 3 Compound: 10	Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay	[PMID: 19394218]

Peso molecular

279.29

Fòrmula

C₁₇H₁₃NO₃

No. CAS

128533-02-8

SMILES

O=C1N(C2=C3C1=CC(O)=C(C3=C4C(C=CC=C4)=C2)OC)C

Structure Classification

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kim SR, et al. Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production. Planta Med. 2004 May;70(5):391-6. [Content Brief]

[2]. Li Z, et al. Saurolactam Inhibits Proliferation, Migration, and Invasion of Human Osteosarcoma Cells. Cell Biochem Biophys. 2015 Jul;72(3):719-26. [Content Brief]

Sauristolactam Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sauristolactam128533-02-8SaurolactamOthersInhibitorinhibitorinhibit

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Sauristolactam (Synonyms: Saurolactam)

Sauristolactam Related Antibodies

Recomendaciones destacadas

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Referencias

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Sauristolactam Related Classifications

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