2. Others Anti-infection
  3. Isotope-Labeled Compounds HCV
  4. Sofosbuvir-d6

Sofosbuvir-d6  (Synonyms: PSI-7977-d6; GS-7977-d6)

Cat. No.: HY-15005S1 Pureza: 98.07%
COA
SDS
Instrucciones de manejo Technical Support

Sofosbuvir-d6 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

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Sofosbuvir-d<sub>6</sub>

Sofosbuvir-d6 Estructura química

No. CAS : 1868135-06-1

Tamaño Precio Stock Cantidad
2 mg Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
5 mg   Obtener un presupuesto  
10 mg   Obtener un presupuesto  
Synthetic products have potential research and development risk.

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of Sofosbuvir-d6:

Sofosbuvir-d6 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sofosbuvir-d6

  • Actividad biológica

  • Pureza y Documentación

  • Revisión del cliente

Descripciòn

Sofosbuvir-d6 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sofosbuvir-d6 Related Antibodies
Peso molecular

535.49

Fòrmula

C22H23D6FN3O9P
No. CAS
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C1N([C@H]2[C@]([C@H](O)[C@@H](CO[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=O)O2)(C)F)C=CC(N1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (93.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 25 mg/mL (46.69 mM; ultrasonic and warming and heat to 50°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8674 mL 9.3372 mL 18.6745 mL
5 mM 0.3735 mL 1.8674 mL 3.7349 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 98.35%

SDS (254 KB)

COA (261 KB) HNMR (161 KB)

Instrucciones de manejo (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.8674 mL 9.3372 mL 18.6745 mL 46.6862 mL
5 mM 0.3735 mL 1.8674 mL 3.7349 mL 9.3372 mL
10 mM 0.1867 mL 0.9337 mL 1.8674 mL 4.6686 mL
15 mM 0.1245 mL 0.6225 mL 1.2450 mL 3.1124 mL
20 mM 0.0934 mL 0.4669 mL 0.9337 mL 2.3343 mL
25 mM 0.0747 mL 0.3735 mL 0.7470 mL 1.8674 mL
30 mM 0.0622 mL 0.3112 mL 0.6225 mL 1.5562 mL
40 mM 0.0467 mL 0.2334 mL 0.4669 mL 1.1672 mL
DMSO 50 mM 0.0373 mL 0.1867 mL 0.3735 mL 0.9337 mL
60 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.7781 mL
80 mM 0.0233 mL 0.1167 mL 0.2334 mL 0.5836 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sofosbuvir-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sofosbuvir-d61868135-06-1PSI-7977-d6GS-7977-d6Isotope-Labeled CompoundsHCVHepatitis C virusInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
Sofosbuvir-d6
Cat. No.:
HY-15005S1
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SAFETY DATA SHEET (SDS)

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