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Taltobulin hydrochloride

HY-15584B

(HTI-286 hydrochloride; SPA-110 hydrochloride)

Taltobulin hydrochloride

Taltobulin hydrochloride Chemical Structure

Taltobulin hydrochloride is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $168 In-stock
5 mg $150 In-stock
10 mg $240 In-stock
50 mg $850 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €165 In-stock
5 mg €147 In-stock
10 mg €235 In-stock
50 mg €833 In-stock
100 mg Get quote
200 mg Get quote

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Product name: Taltobulin hydrochloride
Cat. No.: HY-15584B

Taltobulin hydrochloride Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Taltobulin hydrochloride

Taltobulin hydrochloride is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
IC50 value:
Target: tubulin
in vitro: HTI-286 significantly inhibits proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L). Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 is a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2].
in vivo: Intravenous administration of HTI-286 significantly inhibits tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibits growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy is superior to sequential treatment in the LNCaP model [2].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 510.11 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₇H₄₄ClN₃O₄
CAS No
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.9604 mL 9.8018 mL 19.6036 mL
5 mM 0.3921 mL 1.9604 mL 3.9207 mL
10 mM 0.1960 mL 0.9802 mL 1.9604 mL

References on Taltobulin hydrochloride

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