1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
  2. ADC Cytotoxin

Taltobulin hydrochloride (Synonyms: HTI-286 hydrochloride; SPA-110 hydrochloride)

Cat. No.: HY-15584B
Handling Instructions

Taltobulin hydrochloride is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

For research use only. We do not sell to patients.
Taltobulin hydrochloride Chemical Structure

Taltobulin hydrochloride Chemical Structure

CAS No. :

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $168 In-stock
5 mg $150 In-stock
10 mg $240 In-stock
50 mg $850 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Taltobulin hydrochloride:

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Taltobulin hydrochloride is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin. IC50 value: Target: tubulin in vitro: HTI-286 significantly inhibits proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L). Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 is a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2]. in vivo: Intravenous administration of HTI-286 significantly inhibits tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibits growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy is superior to sequential treatment in the LNCaP model [2].

Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.9604 mL 9.8018 mL 19.6036 mL
5 mM 0.3921 mL 1.9604 mL 3.9207 mL
10 mM 0.1960 mL 0.9802 mL 1.9604 mL






Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

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Taltobulin hydrochloride
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