1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin

Taltobulin hydrochloride (Synonyms: HTI-286 hydrochloride; SPA-110 hydrochloride)

Cat. No.: HY-15584B
Handling Instructions

Taltobulin hydrochloride is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

For research use only. We do not sell to patients.
Taltobulin hydrochloride Chemical Structure

Taltobulin hydrochloride Chemical Structure

CAS No. :

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $168 In-stock
5 mg $150 In-stock
10 mg $240 In-stock
50 mg $850 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Other Forms of Taltobulin hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Taltobulin hydrochloride is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin. IC50 value: Target: tubulin in vitro: HTI-286 significantly inhibits proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L). Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 is a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2]. in vivo: Intravenous administration of HTI-286 significantly inhibits tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibits growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy is superior to sequential treatment in the LNCaP model [2].

References
Molecular Weight

510.11

Formula

C₂₇H₄₄ClN₃O₄

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Taltobulin hydrochloride
Cat. No.:
HY-15584B
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