1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
    Cytoskeleton
  2. ADC Cytotoxin
    Microtubule/Tubulin

Taltobulin trifluoroacetate (Synonyms: HTI-286 trifluoroacetate; SPA-110 trifluoroacetate)

Cat. No.: HY-15584A
Handling Instructions

Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

For research use only. We do not sell to patients.
Taltobulin trifluoroacetate Chemical Structure

Taltobulin trifluoroacetate Chemical Structure

CAS No. : 228266-41-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO $388 In-stock
5 mg $300 In-stock
10 mg $450 In-stock
50 mg $1300 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Taltobulin trifluoroacetate:

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Description

Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin. IC50 value: Target: tubulin in vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2]. in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2].

Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.7016 mL 8.5082 mL 17.0164 mL
5 mM 0.3403 mL 1.7016 mL 3.4033 mL
10 mM 0.1702 mL 0.8508 mL 1.7016 mL
M.Wt

587.67

Formula

C₂₉H₄₄F₃N₃O₆

CAS No.

228266-41-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 39 mg/mL

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Taltobulin trifluoroacetate
Cat. No.:
HY-15584A
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