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Taltobulin trifluoroacetate

HY-15584A

(HTI-286 trifluoroacetate; SPA-110 trifluoroacetate)

Taltobulin trifluoroacetate

Taltobulin trifluoroacetate Chemical Structure

Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $388 In-stock
5 mg $300 In-stock
10 mg $450 In-stock
50 mg $1300 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €380 In-stock
5 mg €294 In-stock
10 mg €441 In-stock
50 mg €1274 In-stock
100 mg Get quote
200 mg Get quote

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Inquiry Information
Product name: Taltobulin trifluoroacetate
Cat. No.: HY-15584A

Taltobulin trifluoroacetate Data Sheet

  • View current batch:

    Purity: 98.52%

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Taltobulin trifluoroacetate

Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
IC50 value:
Target: tubulin
in vitro
: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2].
in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2].

Chemical Information

M.Wt 587.67 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₉H₄₄F₃N₃O₆
CAS No 228266-41-9
Solvent & Solubility

DMSO: ≥ 39 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.7016 mL 8.5082 mL 17.0164 mL
5 mM 0.3403 mL 1.7016 mL 3.4033 mL
10 mM 0.1702 mL 0.8508 mL 1.7016 mL

References on Taltobulin trifluoroacetate

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