1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin

Taltobulin trifluoroacetate (Synonyms: HTI-286 trifluoroacetate; SPA-110 trifluoroacetate)

Cat. No.: HY-15584A
Handling Instructions

Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

For research use only. We do not sell to patients.
Taltobulin trifluoroacetate Chemical Structure

Taltobulin trifluoroacetate Chemical Structure

CAS No. : 228266-41-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 465 In-stock
5 mg USD 360 In-stock
10 mg USD 540 In-stock
50 mg USD 1560 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Taltobulin trifluoroacetate:

  • Biological Activity

  • Protocol

  • Technical Information

  • References


Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin. IC50 value: Target: tubulin in vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2]. in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2].

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7016 mL 8.5082 mL 17.0164 mL
5 mM 0.3403 mL 1.7016 mL 3.4033 mL
10 mM 0.1702 mL 0.8508 mL 1.7016 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







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Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 39 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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