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Products are for research use only. Not for human use. We do not sell to patients.
(HTI-286 trifluoroacetate; SPA-110 trifluoroacetate)
Taltobulin trifluoroacetate Chemical Structure
|Product name: Taltobulin trifluoroacetate|
|Cat. No.: HY-15584A|
Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
in vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure . In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds .
in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) . HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model .
|M.Wt||587.67||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 39 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||1.7016 mL||8.5082 mL||17.0164 mL|
|5 mM||0.3403 mL||1.7016 mL||3.4033 mL|
|10 mM||0.1702 mL||0.8508 mL||1.7016 mL|
. Vashist YK, et al. Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin. World J Gastroenterol. 2006 Nov 14;12(42):6771-8.
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