228266-41-9
Chemical Structure
Taltobulin trifluoroacetate
Synonym(s): HTI-286 trifluoroacetate; SPA-110 trifluoroacetate
- CAS No.: 228266-41-9
- Formula:C29H44F3N3O6
- Molecular Weight:587.67
IUPAC Name: (S,E)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enoic acid compound with 2,2,2-trifluoroacetic acid (1:1)
InChIKey: SHWPCKJNFBDPFA-LPWSJWOVSA-N
SMILES: CC(C)(C)[C@H](NC([C@H](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([C@@H](C(C)C)/C=C(C(O)=O)\C)C)=O.O=C(O)C(F)(F)F
Biological Activity: Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].
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Taltobulin trifluoroacetate | Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. | |||||||||||||||||||||
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Keywords
