1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin

Taltobulin (Synonyms: HTI-286; SPA-110)

Cat. No.: HY-15584 Purity: 99.90%
Handling Instructions

Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

For research use only. We do not sell to patients.

Taltobulin Chemical Structure

Taltobulin Chemical Structure

CAS No. : 228266-40-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 176 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Taltobulin:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin. IC50 value: Target: tubulin in vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2]. in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1113 mL 10.5563 mL 21.1126 mL
5 mM 0.4223 mL 2.1113 mL 4.2225 mL
10 mM 0.2111 mL 1.0556 mL 2.1113 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

473.65

Formula

C₂₇H₄₃N₃O₄

CAS No.

228266-40-8

SMILES

CC(C)(C)[[email protected]](NC([[email protected]](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([[email protected]@H](C(C)C)/C=C(C(O)=O)\C)C)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Taltobulin
Cat. No.:
HY-15584
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Taltobulin

Cat. No.: HY-15584