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Taltobulin

HY-15584

(HTI-286; SPA-110; HTI286; SPA110; HTI 286; SPA 110)

Taltobulin

Taltobulin Chemical Structure

Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $165 In-stock
5 mg $150 In-stock
10 mg $240 In-stock
50 mg $850 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €162 In-stock
5 mg €147 In-stock
10 mg €235 In-stock
50 mg €833 In-stock
100 mg Get quote
200 mg Get quote

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Product name: Taltobulin
Cat. No.: HY-15584

Taltobulin Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Taltobulin

Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
IC50 value:
Target: tubulin
in vitro: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure [1]. In all cell lines tested, HTI-286 was a potent inhibitor of proliferation and induced marked increases in apoptosis. Despite similar transcriptomic changes regarding cell death and cell cycle regulating genes after exposure to HTI-286 or docetaxel, array analysis revealed distinct molecular signatures for both compounds [2].
in vivo: Intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model) [1]. HTI-286 significantly inhibited growth of PC-3 and LNCaP xenografts and retained potency in PC-3dR tumors. Simultaneous castration plus HTI-286 therapy was superior to sequential treatment in the LNCaP model [2].

Chemical Information

M.Wt 473.65 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₇H₄₃N₃O₄
CAS No 228266-40-8
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1113 mL 10.5563 mL 21.1126 mL
5 mM 0.4223 mL 2.1113 mL 4.2225 mL
10 mM 0.2111 mL 1.0556 mL 2.1113 mL

References on Taltobulin

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