2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Carboxypeptidase

Carboxypeptidase

Carboxypeptidase

Related Products

PDF 0.11 MB

Carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of aprotein or peptide. Contrast with an aminopeptidase, which cleaves peptide bonds at the other end of the protein. Humans, animals, and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation. Carboxypeptidases function involved in the indigestion of food, biosynthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing, reproduction, and many other processes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100788
    2-PMPA
    		Inhibitor 98.0%
    2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA is applicable to the research of neurological diseases.
    2-PMPA
  • HY-70005
    CPA inhibitor
    		Inhibitor 99.78%
    CPA inhibitor (Compound 5) (Carboxypeptidase inhibitor) is an orally active competitive carboxypeptidase A (CPA) inhibitor with a Ki value of 0.32 μM. CPA inhibitor blocks the activity of carboxypeptidase A3 (CPA3). CPA activator activates the Wnt/Lrp6/β-catenin signaling pathway. CPA inhibitor reduces epithelial damage. CPA inhibitor is applicable to research related to inflammatory bowel disease, including ulcerative colitis and Crohn's disease.
    CPA inhibitor
  • HY-W096171
    D-Dopa
    		Inhibitor 99.67%
    D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research.
    D-Dopa
  • HY-W704574
    Mergetpa
    		Inhibitor
    Mergetpa is a reversible Arg-carboxypeptidase inhibitor with high affinity. Mergetpa reduces B1R. Mergetpa blocks the overexpression of IL-1β protein and mRNA in glucose-fed rats. Mergetpa significantly increases the expression of IL-1β protein in the renal cortex. Mergetpa is used to block the conversion of kinins and B2 receptor antagonists into metabolites lacking the C-terminal arginine. Mergetpa inhibits the time-dependent enhancement of the response of isolated rabbit aorta to bradykinin. Mergetpa preserves the chemotactic activity of full-length SDF-1α on cells. Mergetpa reverses hyperglycemia, excessive weight gain, elevated levels of oxidative stress markers and overexpression of inflammatory markers in glucose-fed rats.
    Mergetpa
  • HY-W044764
    2-Benzylsuccinic acid
    		Inhibitor 99.83%
    2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis.
    2-Benzylsuccinic acid
  • HY-165571
    E2072
    		Inhibitor
    E2072 is a selective, orally active competitive inhibitor of glutamate carboxypeptidase II (GCPII) with a Ki of 10 nM. E2072 alleviates established thermal hyperalgesia in a rat model of chronic constriction injury. E2072 prevents oxaliplatin-induced reductions in nerve conduction velocity and amplitude in mice. E2072 is applicable to research related to neuropathic pain and neuropathy.
    E2072
  • HY-E70924
    Carboxypeptidase W, Wheat
    Carboxypeptidase W, Wheat (EC 3.4.16.6) belongs to the serine carboxypeptidase family and can be inhibited by diisopropyl fluorophosphate.
    Carboxypeptidase W, Wheat
  • HY-E70958
    Carboxypeptidase G, Pseudomonas sp.
    Carboxypeptidase G, Pseudomonas sp. (EC 3.4.17.11) is a lysosomal thiol-dependent protease that stepwise cleaves γ-glutamylpteroyl polyγ-glutamic acid to generate pteroyl-α-glutamic acid (folic acid) and free glutamic acid. Carboxypeptidase G is highly specific for the γ-glutamyl bond but not for the C-terminal amino acid of the leaving group. Carboxypeptidase G can be activated by Zn2+ ions.
    Carboxypeptidase G, Pseudomonas sp.
  • HY-103345
    2-MPPA
    		Inhibitor 98.0%
    2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM.
    2-MPPA
  • HY-137840
    Hippuryl-L-phenylalanine
    		98.65%
    Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity.
    Hippuryl-L-phenylalanine
  • HY-139840
    GCPII-IN-1
    		Inhibitor 99.83%
    GCPII-IN-1 (Compound 2) is a GCPII (also known as PSMA) inhibitor with a Ki of 44.3 nM. GCPII-IN-1 can be used in the research of prostate cancer.
    GCPII-IN-1
  • HY-100788C
    2-PMPA sodium
    		Inhibitor 99.9%
    2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases.
    2-PMPA sodium
  • HY-12827
    Sortin1
    		Inhibitor 99.54%
    Sortin1 is a vacuolar protein sorting inhibitor that targets carboxypeptidase Y (CPY). Sortin1 is a soluble and membrane vacuolar marker molecule in plants and yeast.
    Sortin1
  • HY-P2981
    Carboxypeptidase C
    Carboxypeptidase C is a carboxypeptidase, is often used in biochemical studies. Carboxypeptidase C removes COOH-terminal lysine, arginine, and proline, as well as all other neutral, aliphatic, aromatic, and the acidic protein amino acids of a peptide chain.
    Carboxypeptidase C
  • HY-118120
    GEMSA
    		Inhibitor 98%
    GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia.
    GEMSA
  • HY-P4236
    Gly-d-Phe
    		99.44%
    Gly-d-Phe is an affinity ligand for Thermolysin (HY-P1748). Gly-d-Phe can be used as the substrate of membrane dipeptidase (MDP).
    Gly-d-Phe
  • HY-W010955
    Z-Phe-Leu-OH
    		Substrate 98.0%
    Z-Phe-Leu-OH (NSC 334018) is a dipeptide acid. Z-Phe-Leu-OH undergoes hydrolysis by carboxypeptidase Y to release L-leucine. Z-Phe-Leu-OH acts as a substrate to assay carboxypeptidase Y peptidase activity.
    Z-Phe-Leu-OH
  • HY-139840A
    GCPII-IN-1 TFA
    		Inhibitor 99.58%
    GCPII-IN-1 (Compound 2) TFA is a GCPII (also known as PSMA) inhibitor with a Ki of 44.3 nM. GCPII-IN-1 TFA can be used in the research of prostate cancer.
    GCPII-IN-1 TFA
  • HY-P4336
    Dansyl-Ala-Arg
    		Substrate 99.36%
    Dansyl-Ala-Arg is a synthetic peptide. Dansyl-Ala-Arg can be used for various biochemical studies.
    Dansyl-Ala-Arg
  • HY-118391
    Benzoyl-L-phenylalanine
    		Inhibitor 99.68%
    Benzoyl-L-phenylalanine (N-Benzoyl-L-phenylalanine) is a chorisate mutase-prephenate dehydrogenase inhibitor.
    Benzoyl-L-phenylalanine
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity