2. Metabolic Enzyme/Protease
  3. Carboxypeptidase
  4. 2-PMPA sodium

2-PMPA sodium  (Synonyms: 2-(Phosphonomethyl)pentanedioic acid sodium)

Cat. No.: HY-100788C Purity: 99.9%
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2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases.

For research use only. We do not sell to patients.

CAS No. : 373645-42-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of 2-PMPA sodium:

2-PMPA sodium Related Antibodies

Top Publications Citing Use of Products

    2-PMPA sodium purchased from MedChemExpress. Usage Cited in: ACS Nano. 2021 Apr 27;15(4):7179-7194.  [Abstract]

    After incubation with 2-PMPA (0.5 mM; 6 h), the uptake of Fluoro-GBP@Fe3O4 (50 μg Fe/mL) in C4-2 cells was assessed by flow cytometry.

    2-PMPA sodium purchased from MedChemExpress. Usage Cited in: ACS Nano. 2021 Apr 27;15(4):7179-7194.  [Abstract]

    2-PMPA (0.5 μM; i.v.; 1-6 h) obviously inhibited the gradual aggregation of GBP@Fe3O4 at the tumor sites in C4-2 tumor-bearing mice.

    • Biological Activity

    • Purity & Documentation

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    • Customer Review

    Description

    2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases[1][2].

    IC50 & Target

    IC50: 300 pM (GCPII)[1]
    In Vitro

    2-PMPA sodium remains stable in rat plasma when stored at room temperature for 4 h, subjected to 3 freeze-thaw cycles, stored at -80°C for 28 days, and placed in a 10°C autosampler for 18 h[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    2-PMPA sodium Related Antibodies
    In Vivo

    2-PMPA (167-250 mg/kg; intraperitoneal injection; single dose) sodium induces a dose-dependent biphasic BOLD signal response in the gray matter of anesthetized mice, with a sustained signal decrease of 2.15-4.64% at 250 mg/kg and a transient signal decrease of 1% at 167 mg/kg[1].
    2-PMPA (80 mg/kg; i.p.; single dose) sodium exerts no significant effects on motor coordination or cognitive ability in Swiss-Webster mice within 24 hours[1].
    2-PMPA (100 mg/kg; intraperitoneal injection; single dose) sodium is rapidly absorbed in male Wistar rats, with low brain penetration (a brain/plasma AUC0-t ratio of 0.018), while it shows higher penetration in peripheral nerve tissues[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Swiss-Webster (SW) (male, approx 6-8 wk old)[2]
    Dosage: 80 mg/kg
    Administration: i.p.; single dose
    Result: Showed mean latency to fall not significantly different from control mice at all tested time points (70, 240, 420, 1440 min post-administration).
    Caused no impairment in motor coordination or cognitive ability observed over the 24-h period.
    Molecular Weight

    314.05

    Formula

    C6H7Na4O7P
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Na])C(CP(O[Na])(O[Na])=O)CCC(O[Na])=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 33.33 mg/mL (106.13 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1842 mL 15.9210 mL 31.8421 mL
    5 mM 0.6368 mL 3.1842 mL 6.3684 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.1842 mL 15.9210 mL 31.8421 mL 79.6052 mL
    5 mM 0.6368 mL 3.1842 mL 6.3684 mL 15.9210 mL
    10 mM 0.3184 mL 1.5921 mL 3.1842 mL 7.9605 mL
    15 mM 0.2123 mL 1.0614 mL 2.1228 mL 5.3070 mL
    20 mM 0.1592 mL 0.7961 mL 1.5921 mL 3.9803 mL
    25 mM 0.1274 mL 0.6368 mL 1.2737 mL 3.1842 mL
    30 mM 0.1061 mL 0.5307 mL 1.0614 mL 2.6535 mL
    40 mM 0.0796 mL 0.3980 mL 0.7961 mL 1.9901 mL
    50 mM 0.0637 mL 0.3184 mL 0.6368 mL 1.5921 mL
    60 mM 0.0531 mL 0.2654 mL 0.5307 mL 1.3268 mL
    80 mM 0.0398 mL 0.1990 mL 0.3980 mL 0.9951 mL
    100 mM 0.0318 mL 0.1592 mL 0.3184 mL 0.7961 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    2-PMPA sodium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    2-PMPA373645-42-22-(Phosphonomethyl)pentanedioic acidCarboxypeptidaseblood-brain barrierNAAG-mGluR3 complexglutamate carboxypeptidase-IIN-acetyl-aspartyl-glutamateN-acetylaspartateischemic brain injuryastrocyte surfacesglutamateBOLD signalanesthetized miceInhibitorinhibitorinhibit

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