373645-42-2
Chemical Structure
2-PMPA sodium
Synonym(s): 2-(Phosphonomethyl)pentanedioic acid sodium
- CAS No.: 373645-42-2
- Formula:C6H7Na4O7P
- Molecular Weight:314.05
IUPAC Name: sodium 2-(phosphonatomethyl)pentanedioate
InChIKey: LEBZXEZQTCDFBJ-UHFFFAOYSA-J
SMILES: O=C(O[Na])C(CP(O[Na])(O[Na])=O)CCC(O[Na])=O
Biological Activity: 2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-PMPA sodium | 99.9% | 2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases. | ||||||||||||||||||||
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- [1]. Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26(1):1-15. [Content Brief]
- [2]. Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). J Pharm Biomed Anal. 2014;88:162-169. [Content Brief]
Keywords
