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Sparfosic acid trisodium 

Cat. No.: HY-112732B
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Sparfosic acid trisodium, is a potent inhibitor of aspartate transcarbamoyl transferase, with anti-tumor and antimetabolite activity. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis.

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Sparfosic acid trisodium Chemical Structure

Sparfosic acid trisodium Chemical Structure

CAS No. : 70962-66-2

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Description

Sparfosic acid trisodium, is a potent inhibitor of aspartate transcarbamoyl transferase, with anti-tumor and antimetabolite activity. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis[1][2].

In Vitro

Sparfosic acid (PALA) treatment causes apoptosis in the resistant Br1 cells[1].
Sparfosic acid (PALA, 300 µM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death[1].

Cell Cycle Analysis[1]

Cell Line: Br-l and L-2 cell lines established from metastasis in nude mouse injected with the human tumor cell line MDA-MB-435.
Concentration: 300 µM.
Incubation Time: 12, 24 and 48 h.
Result: Cells were predominantly in S phase in both the cell lines, although slightly higher proportion of cells in S phase were noted in L-2 than Brl-3prl cells.

Western Blot Analysis[1]

Cell Line: Br-l and L-2 cell lines.
Concentration: 300 µM.
Incubation Time: 4, 10 and 24 h.
Result: There was moderate difference in the level of phosphorylated Rb proteins seen in the two cell types.
Marked increase in the amount of cyclin A protein was detected in the L-2 cells undergoing apoptosis with the highest level detected at 10 h post-drug treatment.
In contrast, there was no increase in the level of cyclin A seen in the Brl-3prl cells.
Cyclin E protein was found elevated in the L-2 cells and Brl-3prl cells compared to their respective controls.
Molecular Weight

321.06

Formula

C₆H₇NNa₃O₈P

CAS No.

70962-66-2

SMILES

O=C(O[Na])C[[email protected]@H](C(O[Na])=O)NC(CP(O)(O[Na])=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Sparfosic acid trisodiumOthersInhibitorinhibitorinhibit

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Sparfosic acid trisodium
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