Cholecystokinin Receptor
CCK Receptor
Cholecystokinin receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin. Two types of functional membrane receptors, cholecystokinin A receptor (CCK-AR), located mainly on pancreatic acinar cells, and CCK-BR, mostly in the stomach and nervous system tissues, have been identified as the endogenous receptors of CCK. Both have high affinity for the sulfated CCK octapeptide (CCK-8), whereas only the CCK-BR has high affinity for gastrin.
CCK is a peptide hormone discovered in the small intestine. Together with secretin and gastrin, CCK constitutes the classical gut hormone triad. In addition to gallbladder contraction, CCK also regulates pancreatic enzyme secretion and growth, intestinal motility, satiety signalling and the inhibition of gastric acid secretion. CCK is also a transmitter in central and intestinal neurons.
Cholecystokinin Receptor Isoform Specific Products
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Cholecystokinin Receptor Inhibitors
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Cholecystokinin Receptor Agonists
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Cholecystokinin Receptor Antagonists
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Cholecystokinin Receptor Activators
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Cholecystokinin Receptor Modulator
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Cholecystokinin Receptor Chemical
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Cholecystokinin Receptor Controls
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Cholecystokinin Receptor Related Products (136)
Related Products (136)
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Cholecystokinin Receptor Isoform Comparison
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CCK (26-31) sulfated
0 ImagesCat. No.: HY-P2677CAS No.: 89911-65-9CCK (26-31) (sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety.
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Cholecystokinin Octapeptide, desulfated TFA
0 ImagesCat. No.: HY-P0196ACAS No.: 171486-94-5Synonyms: CCK Octapeptide, desulfated TFACholecystokinin Octapeptide, desulfated (CCK Octapeptide, desulfated) TFA is a synthetic desulfated Cholecystokinin octapeptide (HY-P0093).
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CCK-B Receptor Antagonist 2
0 ImagesCCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM.
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Mini Gastrin I, human TFA
0 ImagesCat. No.: HY-P1593APurity: 98.13%Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.
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Cholecystokinin-33 free acid
0 ImagesCat. No.: HY-P2932ACholecystokinin-33 free acid is an analogue of Cholecystokinin (HY-P2932). C-terminal amidation is important for binding of Cholecystokinin to its receptors, and removing the amide group would decrease Cholecystokinin activity. Cholecystokinin-33 free acid can be used to study C-terminal amidation of Cholecystokinin-33.
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Tarazepide
0 ImagesCat. No.: HY-U00062CAS No.: 141374-81-4Tarazepide is a potent and specific CCK-A receptor antagonist.
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AG-041R
0 ImagesAG-041R is a potent and selective CCK2 Receptor/Gastrin antagonist. AG-041R inhibits gastrin-evoked secretion of pancreastatin with an IC50 of 2.2 nM. AG-041R inhibits cell growth of Mastomys ECL carcinoid tumor cells.
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Pentagastrin meglumine
0 ImagesCat. No.: HY-A0261ACAS No.: 57448-84-7Synonyms: ICI-50123 megluminePentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCKB) receptor agonist with an EC50 value of 11 nM. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury.
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Gastrazole
0 ImagesCat. No.: HY-19445CAS No.: 862583-15-1Synonyms: JB95008Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer.
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RP 72540
0 ImagesCat. No.: HY-100481CAS No.: 139088-45-2Synonyms: RPR101048RP 72540 is a selective CCK-B receptor antagonist, with IC50 values of 2.4, 1.2, and 3.8 nM for CCK-B receptors in the guinea pig cerebral cortex, rat cerebral cortex, and mouse brain, respectively. RP 72540 effectively inhibits CCK-8-induced neuronal firing and dose-dependently inhibits gastric acid secretion, making it potentially valuable in studies of acid secretion. RP 72540 is an important tool for investigating the physiological functions of CCK B receptors.
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Anthramycin
0 ImagesAnthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice.
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RP73870
0 ImagesCat. No.: HY-114966CAS No.: 197012-43-4RP73870 is an orally active gastrin/cholecystokinin-B receptor antagonist. RP73870 inhibits basal gastric acid secretion in the rat. RP73870 has potent anti-ulcer activity.
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CI-1015
0 ImagesCat. No.: HY-118314CAS No.: 156672-01-4Synonyms: PD 144598CI-1015 is a potent CCK-B receptor antagonist.
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Ro 23-7014
0 ImagesCat. No.: HY-P2592CAS No.: 113714-78-6Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7).
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Mini Gastrin I, human
0 ImagesCat. No.: HY-P1593CAS No.: 54405-27-5Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.
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CE-326597
0 ImagesCat. No.: HY-11074CAS No.: 870615-40-0CE-326597 is a small molecule agonist of the cholecystokinin A receptor (CCKAR). CE-326597 occupies only the lower half of the TMD pocket and cannot mimic the crucial interaction between CCK-8 and ECL1-3. CE-326597 can be used to study metabolic diseases and gastrointestinal dysfunction.
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CI-988 meglumin
0 ImagesCat. No.: HY-105226ACAS No.: 130404-91-0Synonyms: PD134308 megluminCI-988 meglumin is a cholecystokinin 2 receptor (CCK2R) antagonist. CI-988 meglumin prevents the gastrin-mediated protection of the heart with ischemia/reperfusion injury.
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CCK (27-33)
0 ImagesCat. No.: HY-P2627CAS No.: 47910-79-2CCK (27-33) is the C-terminal heptapeptide of cholecystokinin (CCK).
