2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12388
    N-Desmethyl clomipramine
    Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research.
    N-Desmethyl clomipramine
  • HY-W756134
    Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium
    Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium is the deuterium labeled Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium. Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium is a metabolite of Chenodeoxycholic Acid (HY-76847).
    Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d<sub>5</sub> sodium
  • HY-116889
    15-Keto latanoprost acid
    15-keto Latanoprost is a potential metabolite of latanoprost (HY-B0577) when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.1 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 μg/eye.
    15-Keto latanoprost acid
  • HY-136596R
    Apalutamide-COOH (Standard)
    Nortriptyline (Standard) is the analytical standard of Nortriptyline. This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects. N
    Apalutamide-COOH (Standard)
  • HY-W738639
    18-Hydroxy-11-deoxy corticosterone
    18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields.
    18-Hydroxy-11-deoxy corticosterone
  • HY-179369
    4-Hydroxytryptophol
    4-Hydroxytryptophol is an in vitro metabolite of psilocin, can be found in human liver microsomes and recombinant monoamine oxidase A systems. 4-Hydroxytryptophol is not detected in in vivo samples from mice or humans.
    4-Hydroxytryptophol
  • HY-W741033
    Demeton-S sulfone
    Demeton-S sulfone is an oxidative metabolite of the organophosphorus insecticide Disulfoton.
    Demeton-S sulfone
  • HY-44667
    Deacetylmoxisylyte
    Deacetylmoxisylyte is an orally active metabolite in plasma of the prodrug Moxisylyte. Deacetylmoxisylyte exhibits similar affinity and selectivity for rabbit corpus cavernosum and urethra. Deacetylmoxisylyte has IC50 values of 400 and 1200 nM for alpha-1 and alpha-2 adrenoceptors.
    Deacetylmoxisylyte
  • HY-113083A
    Acetaminophen glucuronide potassium
    		99.9%
    Acetaminophen glucuronide potassium (APAP-glu potassium) is the inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen glucuronide potassium can be used as a biomarker to measure glucuronidation activity or hepatic drug metabolism capacity.
    Acetaminophen glucuronide potassium
  • HY-W702646
    Hydroxymethyl tolperisone hydrochloride
    		Control
    Hydroxymethyl tolperisone hydrochloride is a metabolite of Tolperisone (HY-B1139A). Hydroxymethyl tolperisone hydrochloride is formed from tolperisone primarily by the cytochrome P450 (CYP) isoform CYP2D6 and to a lesser extent by CYP2C19 and CYP1A2.
    Hydroxymethyl tolperisone hydrochloride
  • HY-W700741
    2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride
    		Control
    2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride is a metabolite of the anorectic agent Mazindol.
    2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride
  • HY-B0602B
    Desvenlafaxine fumarate
    Desvenlafaxine (O-Desmethylvenlafaxine) fumarate is a selective serotonin and norepinephrine reuptake inhibitor. Desvenlafaxine (O-Desmethylvenlafaxine) fumarate is the major metabolite of the antidepressant venlafaxine. Desvenlafaxine (O-Desmethylvenlafaxine) fumarate has the potential for the research of depression and related disorders and diseases (extracted from patent WO2009049354A1).
    Desvenlafaxine fumarate
  • HY-W557590
    Nabumetone alcohol
    Nabumetone alcohol is a metabolite of Nabumetone (HY-B0559). Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers.
    Nabumetone alcohol
  • HY-137697A
    ddCTP tetrasodium
    ddCTP tetrasodium is a type of chain-terminating deoxynucleotide. ddCTP tetrasodium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP tetrasodium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP tetrasodium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication.
    ddCTP tetrasodium
  • HY-G0018S
    Norgestimate metabolite norelgestromin-d6
    		99.90%
    Norgestimate metabolite norelgestromin-d6 is the deuterium labeled Norgestimate metabolite norelgestromin. Norelgestromin is a metabolite of Norgestimate, which is a progestin or synthetic progestogen. Norgestimate metabolite norelgestromin-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norgestimate metabolite norelgestromin-d<sub>6</sub>
  • HY-126857AS1
    5-Hydroxyomeprazole-13C,d2 sodium
    5-Hydroxyomeprazole-13C,d2 sodium is 13C and deuterated labeled 5-Hydroxyomeprazole sodium (HY-126857A).
    5-Hydroxyomeprazole-<sup>13</sup>C,d<sub>2</sub> sodium
  • HY-W700344
    o-Desmethyl ranolazine
    o-Desmethyl ranolazine (CVT-2514; RS-88390) is a metabolite of Ranolazine (HY-B0280), formed through metabolism of Ranolazine by enzymes of the cytochrome P450 (CYP) 3A family.
    o-Desmethyl ranolazine
  • HY-119904R
    Malaoxon (Standard)
    Malaoxon (Standard) is the analytical standard of Malaoxon. This product is intended for research and analytical applications. Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity.
    Malaoxon (Standard)
  • HY-W653822
    (2'S)-Nicotine 1-oxide
    (2'S)-Nicotine 1-oxide ((2S)-Nicotine 1-N-oxide) is an alkaloid N-oxide, which is found in leaves, stems and roots of Nicotiana tabacum.
    (2'S)-Nicotine 1-oxide
  • HY-114689
    Diclofenac methyl ester
    		98.04%
    Diclofenac methyl ester is a metabolite of Diclofenac (HY-15036), which exhibits acute cytotoxicity with a LC50 of 0.5 mg/L in H. azteca.
    Diclofenac methyl ester
Cat. No. Product Name / Synonyms Application Reactivity