ddCTP tetrasodium
ddCTP tetrasodium is a type of chain-terminating deoxynucleotide. ddCTP tetrasodium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP tetrasodium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP tetrasodium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication.
For research use only. We do not sell to patients.
- Formula: C9H12N3Na4O12P3
- Molecular Weight:539.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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DNA Polymerase |
ddCTP (0.1 mM; 20 min) tetrasodium enables discrimination of nearly identical RNA sequences via chain termination during poisoned primer extension reactions using total cellular RNA or purified in vitro transcripts, generating extension products of distinct sizes detectable by gel electrophoresis[1].
ddCTP tetrasodium, in addition to inhibiting viral reverse transcriptase, may also inhibit DNA polymerase γ in mammalian cells. This enzyme is responsible for mitochondrial DNA synthesis. Inhibition of DNA polymerase γ leads to decreased mitochondrial DNA content and impaired function[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 539.08
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Formula C9H12N3Na4O12P3
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SMILES
O=[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H]1CC[C@H](N2C(N=C(N)C=C2)=O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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