4-Hydroxytryptophol  (Synonyms: 4-HTP)

4-Hydroxytryptophol is an in vitro metabolite of psilocin, can be found in human liver microsomes and recombinant monoamine oxidase A systems. 4-Hydroxytryptophol is not detected in in vivo samples from mice or humans[1].

4-Hydroxytryptophol is produced in minor amounts (43.4 nM) alongside a 29% decrease in psilocin concentration when 1,000 nM psilocin is incubated with human liver microsomes for 240 minutes^[1].
4-Hydroxytryptophol is produced in minor amounts (16.9 nM) without a visible decrease in psilocin concentration when 1,000 nM psilocin is incubated with recombinant MAO-A enzymes for 300 minutes^[1].
4-Hydroxytryptophol shows no relevant binding affinity to human 5-HT_1A, 5-HT_2A, and 5-HT_2C receptors (K_i > 10,000 nM) in HEK 293 cell line membrane preparations^[1].
4-Hydroxytryptophol shows no relevant activation potency at human 5-HT_1A, 5-HT_2A, and 5-HT_2B receptors (EC₅₀ > 10,000 nM) in NIH/3T3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

177.20

C₁₀H₁₁NO₂

1379213-90-7

OC1=CC=CC2=C1C(CCO)=CN2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. HY-179369.pdf  [Content Brief]