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Cat. No.: HY-179369

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4-Hydroxytryptophol

(Synonyms: 4-HTP)

4-Hydroxytryptophol is an in vitro metabolite of psilocin, can be found in human liver microsomes and recombinant monoamine oxidase A systems. 4-Hydroxytryptophol is not detected in in vivo samples from mice or humans.

For research use only. We do not sell to patients.

CAS No.: 1379213-90-7
Formula: C₁₀H₁₁NO₂
Molecular Weight:177.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

4-Hydroxytryptophol Chemical Structure

CAS No.: 1379213-90-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

4-Hydroxytryptophol is produced in minor amounts (43.4 nM) alongside a 29% decrease in psilocin concentration when 1,000 nM psilocin is incubated with human liver microsomes for 240 minutes^[1].
4-Hydroxytryptophol is produced in minor amounts (16.9 nM) without a visible decrease in psilocin concentration when 1,000 nM psilocin is incubated with recombinant MAO-A enzymes for 300 minutes^[1].
4-Hydroxytryptophol shows no relevant binding affinity to human 5-HT_1A, 5-HT_2A, and 5-HT_2C receptors (K_i > 10,000 nM) in HEK 293 cell line membrane preparations^[1].
4-Hydroxytryptophol shows no relevant activation potency at human 5-HT_1A, 5-HT_2A, and 5-HT_2B receptors (EC₅₀ > 10,000 nM) in NIH/3T3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1379213-90-7
Molecular Weight 177.20
Formula C₁₀H₁₁NO₂
SMILES

OC1=CC=CC2=C1C(CCO)=CN2
Synonyms

4-HTP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. HY-179369.pdf [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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