2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125694
    MFB-1041
    		Inhibitor
    MFB-1041 is an orally active antifungal agent, but exhibits poor oral absorption. MFB-1041 induces the binding of drug to serum albumin.
    MFB-1041
  • HY-N14426
    Concanamycin F
    		Inhibitor
    Concanamycin F has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research.
    Concanamycin F
  • HY-N15595
    Curvulol
    		Inhibitor
    Curvulol is an antimicrobial agent with a polyketide structure. Curvulol can be isolated from Taxus baccata ( Chaetosphaeronema achilleae). Curvulol has a significant cytotoxicity against L929 and KB-3-1 cells, and strongly inhibits Staphylococcus aureus biofilm formation with a MIC of 64 μg/mL.
    Curvulol
  • HY-178189
    Laccase-IN-6
    		Inhibitor
    Laccase-IN-6 is a laccase inhibitor with an IC50 of 0.097 nM. Laccase-IN-6 exhibits broad-spectrum anti-fungal effect and can destroy the normal morphology of the fungi. Laccase-IN-6 can be used for the research of infection.
    Laccase-IN-6
  • HY-169812
    Dihydrobiochanin A
    		Inhibitor
    Dihydrobiochanin A has antifungal activity. Dihydrobiochanin A is a flavonoid that can isolated from Swartzia polyphylla.
    Dihydrobiochanin A
  • HY-170378
    Laccase-IN-5
    		Inhibitor
    Laccase-IN-5 (Compound 2b) is the inhibitor for Laccase with an IC50 of 0.82 μM. Laccase-IN-5 increases the cell membrane permeability, limits the growth of hyphae, destorys the cell wall, and induces oxidative stress responses. Laccase-IN-5 exhibits antifungal activity against various plant pathogenic fungi and oomycetes, inhibits B. dothidea with an EC50 of 0.96 mg/L.
    Laccase-IN-5
  • HY-129585
    SM-4470
    		Inhibitor
    SM-4470 is an orally active antifungal compound. SM-4470 has inhibitory activity against yeast, Aspergillus, and dermatophytes in vitro.
    SM-4470
  • HY-124408R
    Mepronil (Standard)
    		Inhibitor
    Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection.
    Mepronil (Standard)
  • HY-N14547
    Crotocin
    		Inhibitor
    Crotocin has the fungal activity of anti-cryptococcus neoforme, candida albicans, Tinea trichoderma of brewer's yeast, and can be inactivated by blood.
    Crotocin
  • HY-N14219
    Enactin Ⅴa
    		Inhibitor
    Enactin Va is found in the strain of Streptomyces roseoviridis. Enactin Va has only weak antifungal activity.
    Enactin Ⅴa
  • HY-179704
    Antifungal agent 141
    		Inhibitor
    Antifungal agent 141, a Phenoxazine (HY-34463) derivative, is an antifungal agent. Antifungal agent shows potent antifungal activity in Cryptococcus neoformans and Candida albicans with MIC values of 2 and 4 µg/mL. Antifungal agent 141 can be used for the research of cryptococcal meningitis.
    Antifungal agent 141
  • HY-107126AR
    Ibrexafungerp citrate (Standard)
    		Inhibitor
    Ibrexafungerp citrate (Standard) (MK 3118 citrate (Standard)) is the analytical standard of Ibrexafungerp (citrate) (HY-107126A). This product is intended for research and analytical applications. Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections.
    Ibrexafungerp citrate (Standard)
  • HY-W748023
    Cryptosporiopsin A
    		Inhibitor
    Cryptosporiopsin A, a polyketide with antifungal activity, exhibits motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola.
    Cryptosporiopsin A
  • HY-N14527
    Octacosamicin B
    		Inhibitor
    Octacosamicin B has the function of resisting bacterium, yeast, and filamentous fungus, but the function of resisting bacterium is weak.
    Octacosamicin B
  • HY-B0450AR
    Ciclopirox olamine (Standard)
    		Inhibitor
    Ciclopirox (olamine) (Standard) is the analytical standard of Ciclopirox (olamine). This product is intended for research and analytical applications. Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect.
    Ciclopirox olamine (Standard)
  • HY-129316
    (S)-Dihydroaeruginoic acid
    		Inhibitor
    (S)-Dihydroaeruginoic acid is an antibiotic originally isolated from P. fluorescens. It has antimicrobial activity in a disc assay against R. solani, P. ultimum, B. cinera, S. rolfsii, C. gloeosporioide, F. oxysporum, and S. tritici fungi as well as B. subtilis, E. herbicola, and S. albus bacteria when used at a concentration of 200 μg/disc.
    (S)-Dihydroaeruginoic acid
  • HY-N14856
    Verlamelin
    		Inhibitor
    Verlamelin is a depsipeptide antibiotic. Verlamelin has anti-fungal activity against plant pathogens.
    Verlamelin
  • HY-W715444
    Mucidin
    		Inhibitor
    Mucidin is an antifungal antibiotic that inhibits electron-transfer reactions in the cytochrome bc1 complex of the mitochondrial respiratory chain.
    Mucidin
  • HY-W725177
    Inpyrfluxam
    		Inhibitor
    Inpyrfluxam is a succinate dehydrogenase (SDH) inhibitor. Inpyrfluxam targets the ubiquinone binding pocket of mitochondrial SDH complex subunits ViSDHB, ViSDHC, ViSDHD, interfering with cellular respiration. Inpyrfluxam inhibits conidial germination and mycelial growth of Venturia inaequalis in vitro. Inpyrfluxam can be used for the research of apple scab.
    Inpyrfluxam
  • HY-101938R
    Sinefungin (Standard)
    		Inhibitor
    Sinefungin (Standard) is the analytical standard of Sinefungin (HY-101938). This product is intended for research and analytical applications. Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation.
    Sinefungin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity