Fungal

Related Products

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (2639)
Antibodies (1)
Related Compound Screening Libraries (1)

By Effects:	Inhibitors (2351)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-181492

Antifungal agent 155 hydrochloride	Inhibitor
Antifungal agent 155 hydrochloride is an antifungal agent. Antifungal agent 155 hydrochloride induces bent, twisted, abnormally swollen hyphae, compromises fungal hyphal plasma membrane integrity, and triggers fungal cell death. Antifungal agent 155 hydrochloride can be used for the research of fusarium keratitis.

HY-N13994

Clavamycin A	Inhibitor
Clavamycin A has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.

HY-W019852R

Flutriafol (Standard)	Inhibitor
Flutriafol (Standard) is the analytical standard of Flutriafol. This product is intended for research and analytical applications. Flutriafol is a triazole fungicide with broad spectrum fungicidal activity.

HY-125606

Amphocil	Inhibitor
Amphocil is an equimolar mixture of Amphotericin B (HY-B0221) and cholesteryl sulphate with antifungal effects. Amphocil is promising for research of disseminated cryptococcosis.

HY-N14788

Cephemimycin	Inhibitor
Cephemimycin has weak antibacterial and antifungal activity.

HY-135141

Tetrahydroechinocandin B	Inhibitor
Tetrahydroechinocandin B (L 687,901) is a potent antifungal agent. Tetrahydroechinocandin B inhibits 1,3-beta-D-glucan synthesis with an IC₅₀ of 0.85 μg/mL.

HY-N6051R

(-)-Maackiain (Standard)	Inhibitor
(-)-Maackiain (Standard) is the analytical standard of (-)-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active.

HY-N14040

Crocacin B	Inhibitor
Crocacin B has anti-yeast and filamentous fungal activity. Crocacin B can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin B can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.

HY-165494

Oudemansin A	Inhibitor
Oudemansin A is an antibiotic. Oudemansin A acts on fungi to inhibit protein, RNA and DNA synthesis.

HY-Y0055R

Phenothiazine (Standard)	Inhibitor
Phenothiazine (Standard) is the analytical standard of Phenothiazine. This product is intended for research and analytical applications. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases.

HY-B1790R

Terconazole (Standard)	Inhibitor
Terconazole (Standard) is the analytical standard of Terconazole. This product is intended for research and analytical applications. Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.

HY-N13915

Scorodonin	Inhibitor
Scorodonin has anti-bacterial, Streptomyces and fungal effects. Scorodonin inhibits DNA-dependent RNA polymerases with an IC₅₀ of 25 μg/mL.

HY-N14824

Neoenactin M2	Inhibitor
Neoenactin M2 has strong anti-yeastlike and filamentous fungal effects.

HY-N14560

Cyclopaldic acid	Inhibitor
Cyclopaldic acid of 2.5 μg/mL can inhibit the spore germination of Garlic botrytis spore 95%-100%.

HY-174353

CYP51-IN-22	Inhibitor
CYP51-IN-22, the non-deuterated analog of CYP51-IN-23-d₃ (HY-174353S), is a potent and broad-spectrum CYP51 inhibitor.CYP51-IN-22 inhibits Aspergillus fumigatum with a MIC₈₀ of 1 μg/mL. CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs).

HY-N14151

Darlucin B	Inhibitor
Darlucin B has antibacterial and fungi activity, and weak cytotoxicity.

HY-101293R

VU0359595 (Standard)	Inhibitor
VU0359595 (Standard) is the analytical standard of VU0359595 (HY-101293). This product is intended for research and analytical applications. VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC50 of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases.

HY-165191

LY214352	Inhibitor
LY214352 is an antifungal agent that targets dihydroorotate dehydrogenase (DHO-DH). LY214352 exhibits antifungal activity against Aspergillus nidulans and agriculturally important ascomycete fungi. LY214352 can be used in studies related to grape gray mold, apple scab, and fungal infections caused by ascomycetes.

HY-125459

L 705589	Inhibitor
L-705589 is a semi-synthetic penicillin-type antifungal agent. L-705589 exerts its antifungal effect by inhibiting the 1,3-β-D-glucan synthase in the fungal cell wall. L-705589 exhibits potent bactericidal activity against various Candida species (such as Candida albicans, Candida glabrata, Candida krusei, etc.) (MFC: 0.06 - 8 μg/mL), but has relatively weak activity against Cryptococcus neoformans (MFC: 32 - 64 μg/mL). L-705589 remains active against drug-resistant Candida strains and is not prone to inducing drug resistance. L-705589 significantly improves survival rates in the model of minor invasive aspergillosis.