2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123230S
    Trifloxystrobin-d6
    		Inhibitor
    Trifloxystrobin-d6 is the deuterium labeled Trifloxystrobin. Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h.
    Trifloxystrobin-d<sub>6</sub>
  • HY-162458
    Antifungal agent 100
    		Inhibitor
    Antifungal agent 100 (compound 3i) exhibits significant antifungal effects against S. sclerotiorum with an EC50 value of 0.33 mg/L. Antifungal agent 100 displays an IC50 of 0.63 mg/mL against the Succinate dehydrogenase (SDH) of S. sclerotiorum.
    Antifungal agent 100
  • HY-183966
    Antibacterial agent 348
    		Inhibitor
    Antibacterial agent 348 is an antimicrobial agent containing piperazine-isopropanolamine bifunctional groups. Antibacterial agent 348 suppresses virulence factor expression in plant pathogens. Antibacterial agent 348 compromises bacterial membrane integrity, leading to cytoplasmic leakage. Antibacterial agent 348 inhibits cellular proliferation of plant pathogens, diminishes colonization and infectivity of plant pathogens in host plants. Antibacterial agent 348 can be used for the research of rice bacterial leaf blight, pepper phytophthora blight.
    Antibacterial agent 348
  • HY-B0101S1
    Fluconazole-13C2,15N
    		Inhibitor
    Fluconazole-13C2,15N (UK-49858-13C2,15N) is the 13C and 15N labeled isotope of Fluconazole (HY-B0101). Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL.
    Fluconazole-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-P11193
    Scolopin-2
    		Inhibitor
    Scolopin-2 is an antimicrobial peptide that can be isolated from centipede venoms. Scolopin-2 shows strong antimicrobial activities against a panel of Gram-positive/negative bacteria and fungi (MIC ≤ 7.5 μg/mL) . Scolopin-2 shows moderate hemolytic activity against both human and rabbit red cells. Scolopin-2 can be used for antimicrobial research.
    Scolopin-2
  • HY-167879
    (Rac)-NPD6433
    		Inhibitor
    (Rac)-NPD6433 is a racemate of NPD6433. NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis.
    (Rac)-NPD6433
  • HY-123025
    Schizozygine
    		Inhibitor
    Schizozygine is an alkaloid that can be isolated from Schizozygia caffaeoides. Schizozygia caffaeoides has been used as a traditional medicine for skin disease. The leaf extracts has high antifungal and antimicrobial activity.
    Schizozygine
  • HY-16561S1
    Resveratrol-13C6
    		Inhibitor
    Resveratrol-13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
    Resveratrol-<sup>13</sup>C<sub>6</sub>
  • HY-P2763
    beta-Glucanase
    		Inhibitor
    beta-Glucanase belongs to glycosyl hydrolase family that hydrolyzes β-glucan polysaccharide, producing 3-O-cellotriosyl-d-glucose and 3-O-cellobiosyl-d-glucose. beta-Glucanase is capable of protecting plants against different fungal pathogens.
    beta-Glucanase
  • HY-131134S
    Fosetyl-aluminum-d15
    		Inhibitor
    Fosetyl-aluminum-d15 (Fosetyl-Al-d15) is the deuterium labeled Fosetyl-aluminum. Fosetyl-aluminum (Fosetyl-Al) is an active ingredient in many fungicides against downy mildew. Fosetyl-aluminum is used to control many diseases caused by Phytophthora spp. on agricultural and horticultural crops.
    Fosetyl-aluminum-d<sub>15</sub>
  • HY-N19799
    Diorcinol D
    		Inhibitor
    Diorcinol D is a natural product with antifungal activity. Diorcinol D inhibits CYP51 expression, reduces Cdr1 expression, blocks efflux pump activity, and impedes ergosterol biosynthesis. It inhibits planktonic and biofilm growth of Candida albicans. Diorcinol D is applicable to research related to fungal infections.
    Diorcinol D
  • HY-132912
    Antifungal agent 15
    		Inhibitor
    Antifungal agent 15 has the most potent activity with EC50 values of 0.52 and 0.50 μg/mL against S. sclerotiorum and B. cinerea, respectively.
    Antifungal agent 15
  • HY-120432
    CaMdr1p-IN-1
    		Inhibitor
    CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM.
    CaMdr1p-IN-1
  • HY-N2563
    Neocnidilide
    		Inhibitor 98.63%
    Neocnidilide is an alkylphthalide, which has the activity of inhibiting the growth of mycotoxin-producing fungi. Neocnidilide also has larvicidal activity against D. melanogaster with a LC50 value of 9.9 μmol/mL.
    Neocnidilide
  • HY-126724R
    Flutianil (Standard)
    		Inhibitor
    Flutianil (Standard) is the analytical standard of Flutianil. This product is intended for research and analytical applications. Flutianil is a fungicide, which specifically inhibits the powdery mildew species. Flutianil inhibits the haustorium formation and subsequent mycelia growth.
    Flutianil (Standard)
  • HY-123565
    TP-S1-68
    		Inhibitor
    TP-S1-68 (Compound 10) is a TIE-2 inhibitor with an IC50 of 3.65 μM. TP-S1-68 exhibits antibacterial activity against a variety of fungal and bacteria. TP-S1-68 serves as a starting compound for the further development of TIE-2 inhibitors. TP-S1-68 can be used in research related to solid tumors, bacterial infections and fungal infections.
    TP-S1-68
  • HY-119759AR
    Lipoxamycin hemisulfate (Standard)
    		Inhibitor
    Lipoxamycin (hemisulfate) (Standard) is the analytical standard of Lipoxamycin (hemisulfate). This product is intended for research and analytical applications. Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].
    Lipoxamycin hemisulfate (Standard)
  • HY-W512253
    4-Hydroxyflavan
    		Inhibitor
    4-Hydroxyflavan is a hydroxyflavan that exhibits antifungal activities against sporelings of B. cinerea (ED50 = 216 μM). 4-Hydroxyflavan can be used for antifungal research.
    4-Hydroxyflavan
  • HY-N1650
    Pygenic acid B
    		Inhibitor
    Pygenic acid B is a triterpenoid that can be isolated from the leaves of Glochidion obliquum. Pygenic acid B shows antifungal activity against C. musae. Pygenic acid B shows ONOO- scavenging activity.
    Pygenic acid B
  • HY-W017143
    Antifungal agent 158
    		Inhibitor
    Antifungal agent 158 is an α-pyrone derivative that can be found in Trichoderma harzianum, exhibiting antifungal activity against select plant-pathogenic fungi, including Chaetomium spp., Curvularia lunata, and Aspergillus flavus. Antifungal agent 158 is non-toxic to greenhouse-grown bean, corn, and tobacco plants. Antifungal agent 158 can be used for research on Aspergillus flavus infection.
    Antifungal agent 158
Cat. No. Product Name / Synonyms Application Reactivity